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PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, P. falciparum.

ABSTRACT: Enrichment of PfMORC-HA associated proteins by HA immunoprecipitation from P. falciparum parasites expressing P. falciparum MORC tagged with a 3xHA tag.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Plasmodium Falciparum (ncbitaxon:5833)

SUBMITTER: Laurence Florens

PROVIDER: MSV000092353 | MassIVE | Thu Jul 06 06:19:00 BST 2023

SECONDARY ACCESSION(S): PXD043582

REPOSITORIES: MassIVE

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PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum.

Chahine Z Z Gupta M M Lenz T T Hollin T T Abel S S Banks Cas C Saraf A A Prudhomme J J Bhanvadia S S Florens L L Le Roch K G KG

bioRxiv : the preprint server for biology 20240827

The environmental challenges the human malaria parasite, Plasmodium falciparum, faces during its progression into its various lifecycle stages warrant the use of effective and highly regulated access to chromatin for transcriptional regulation. Microrchidia (MORC) proteins have been implicated in DNA compaction and gene silencing across plant and animal kingdoms. Accumulating evidence has shed light into the role MORC protein plays as a transcriptional switch in apicomplexan parasites. In ...[more]

PMID: 37745554

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