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Altered proteomic events induced by a beta in SHSY5Y

ABSTRACT: To explore the physiological mechanism of A betain vitro, we employed mass spectrometry to investigate the altered proteomic events induced by lower submicromolar con-centration of A beta. Human neuroblastoma SH-SY5Y cells were incubated with five dif-ferent concentrations of A beta1-40 monomers and collected at four time points. The pro-teomic results found the time-course behavior of proteins involved in biological pro-cesses, such as RNA splicing, nuclear transport and protein localization.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: chenxi yang

PROVIDER: MSV000095188 | MassIVE | Sun Jun 30 03:47:00 BST 2024

SECONDARY ACCESSION(S): PXD053519

REPOSITORIES: MassIVE

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