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LC/MS analysis for proteome of SHSY5Y induced by a beta

ABSTRACT: To explore the physiological mechanism of A beta in vitro, we employed mass spectrometry to investigate the altered proteomic events induced by lower submicromolar concentration of A beta. Human neuroblastoma SH-SY5Y cells were incubated with five different concentrations of A beta1-40 monomers and collected at four time points. The proteomic results found the time-course behavior of proteins involved in biological processes, such as RNA splicing, nuclear transport and protein localization.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: chenxi yang

PROVIDER: MSV000095199 | MassIVE | Mon Jul 01 05:26:00 BST 2024

SECONDARY ACCESSION(S): PXD053527

REPOSITORIES: MassIVE

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