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Label-free global proteome profiling of European American and African American bladder tumor patients.

ABSTRACT: Bladder cancer (BLCA) mortality is higher in African American (AA) patients compared to their European American (EA) counterparts, but the molecular mechanism underlying differences are unknown. . Thus, we performed proteomics analysis of AA and EA BLCA and identified higher mitochondrial OXPHOS specifically through complex I activation in AA BLCA.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Sung Yun Jung

PROVIDER: MSV000095559 | MassIVE | Thu Aug 08 17:00:00 BST 2024

SECONDARY ACCESSION(S): PXD054731

REPOSITORIES: MassIVE

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Mitochondrial reprogramming by activating OXPHOS via glutamine metabolism in African American patients with bladder cancer.

Kami Reddy Karthik Reddy KR Piyarathna Danthasinghe Waduge Badrajee DWB Park Jun Hyoung JH Putluri Vasanta V Amara Chandra Sekhar CS Kamal Abu Hena Mostafa AHM Xu Jun J Kraushaar Daniel D Huang Shixia S Jung Sung Yun SY Eberlin Livia S LS Johnson Jabril R JR Kittles Rick A RA Ballester Leomar Y LY Parsawar Krishna K Siddiqui M Minhaj MM Gao Jianjun J Langer Gramer Adriana A Bollag Roni J RJ Terris Martha K MK Lotan Yair Y Creighton Chad J CJ Lerner Seth P SP Sreekumar Arun A Kaipparettu Benny Abraham BA Putluri Nagireddy N

JCI insight 20240910 17

Bladder cancer (BLCA) mortality is higher in African American (AA) patients compared with European American (EA) patients, but the molecular mechanism underlying race-specific differences are unknown. To address this gap, we conducted comprehensive RNA-Seq, proteomics, and metabolomics analysis of BLCA tumors from AA and EA. Our findings reveal a distinct metabolic phenotype in AA BLCA characterized by elevated mitochondrial oxidative phosphorylation (OXPHOS), particularly through the activation ...[more]

PMID: 39253977

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