Proteomics

Dataset Information

0

Deep motif deconvolution of HLA-II peptidomes

ABSTRACT: CD4 T cells are key for priming and regulating immune recognition of infected and cancer cells, but predictions of class II epitopes have limited accuracy. We profiled over 100’000 HLA-II ligands by Mass Spectrometry and developed a novel motif deconvolution algorithm to analyze these data. Our work demonstrates substantial improvements in the definition of HLA-II binding motifs and enhanced accuracy in HLA-II ligand and class II epitope predictions.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Michal Bassani-Sternberg  

PROVIDER: MSV000096130 | MassIVE | Fri Oct 18 10:18:00 BST 2024

SECONDARY ACCESSION(S): PXD012308

REPOSITORIES: MassIVE

Json Xml

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1
altmetric image

Publications

Predictions of epitopes presented by class II human leukocyte antigen molecules (HLA-II) have limited accuracy, restricting vaccine and therapy design. Here we combined unbiased mass spectrometry with a motif deconvolution algorithm to profile and analyze a total of 99,265 unique peptides eluted from HLA-II molecules. We then trained an epitope prediction algorithm with these data and improved prediction of pathogen and tumor-associated class II neoepitopes. ...[more]

Similar Datasets

Proteomics Deep motif deconvolution of HLA-II peptidomes
2019-10-16 | PXD012308 | Pride
Proteomics HLA-I and HLA-II peptidomes for NESSIE
2024-08-08 | PXD047303 | JPOST Repository
Proteomics HLA-I and HLA-II peptidomes of endometrial cancer
2024-10-31 | PXD050576 | JPOST Repository
Proteomics Large-Scale Immuno-Peptidome Analysis Reveals Recurrent Post-Translational Splicing of Cancer and Immune-Associated Genes
2023-05-10 | PXD034788 | Pride
Genomics HLA Class I/II submissions 240607
| PRJEB76430 | ENA
Genomics undefined
| PRJEB41853 | ENA
Genomics Full-length HLA class II sequences
| PRJEB42469 | ENA
Genomics Gene and protein sequence features augment HLA class I ligand predictions.
| PRJNA868572 | ENA
Proteomics Mass spectrometric profiling of HLA-B44 peptidomes provides evidence for tapasin-mediated tryptophan editing
2024-07-15 | PXD046825 | Pride
Transcriptomics Gene and protein sequence features augment HLA class I ligand predictions (mRNA sequencing)
2023-01-08 | GSE210999 | GEO