Dataset Information

Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster

ABSTRACT: Metabolites are active controllers of cellular physiology, but their role in complex behaviors is less clear. Here we report the metabolic changes that occur during the transition between hunger and satiety in Drosophila melanogaster. To analyze these data in the context of fruit fly metabolic networks, we developed Flyscape, an open-access tool. We show that in response to eating, metabolic profiles change in quick, but distinct ways in the heads and bodies. Consumption of a high sugar diet dulls the metabolic and behavioral differences between the fasted and fed state, and reshapes the way nutrients are utilized upon eating. Specifically, we found that high dietary sugar increases TCA cycle activity, alters neurochemicals, and depletes 1-carbon metabolism and brain health metabolites N-acetyl-aspartate and kynurenine. Together, our work identifies the metabolic transitions that occur during hunger and satiation, and provides a platform to study the role of metabolites and diet in complex behavior.

INSTRUMENT(S): Q Exactive

SUBMITTER: MONICA DUS

PROVIDER: MTBLS180 | MetaboLights | 2019-07-13

REPOSITORIES: MetaboLights

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Dataset's files

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			Action	DRS
	MTBLS180	Other
	FILES	Other
	a_MTBLS180_Method1_POS_1_metabolite_profiling_mass_spectrometry.txt	Txt
	a_MTBLS180_Method2_POS_2_metabolite_profiling_mass_spectrometry.txt	Txt
	a_MTBLS180_Method3_NEG_1_metabolite_profiling_mass_spectrometry.txt	Txt

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Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster.

Wilinski Daniel D Winzeler Jasmine J Duren William W Persons Jenna L JL Holme Kristina J KJ Mosquera Johan J Khabiri Morteza M Kinchen Jason M JM Freddolino Peter L PL Karnovsky Alla A Dus Monica M

Nature communications 20190906 1

Metabolites are active controllers of cellular physiology, but their role in complex behaviors is less clear. Here we report metabolic changes that occur during the transition between hunger and satiety in Drosophila melanogaster. To analyze these data in the context of fruit fly metabolic networks, we developed Flyscape, an open-access tool. We show that in response to eating, metabolic profiles change in quick, but distinct ways in the heads and bodies. Consumption of a high sugar diet dulls t ...[more]

PMID: 31492856

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