Dataset Information
Tissue, urine and serum NMR metabolomics dataset from a 5/6 nephrectomy rat model of chronic kidney disease
Ontology highlight
ABSTRACT: Serum, urine and tissue from a rat model of chronic kidney disease (CKD) were analysed using nuclear magnetic resonance (NMR) spectroscopy-based metabolomics methods, and compared with samples from sham operated rats. Both urine and serum were sampled at multiple timepoints, and the results have been reported elsewhere [1]. The data could be useful to researchers working with human CKD or rat models of the disease. In addition, several different types of NMR spectra were recorded, including 1D NOESY, CPMG, and 2D J-resolved spectra, and the data could be useful for method comparison and algorithm development, both in terms of NMR spectroscopy and multivariate analysis. References: [1] Hanifa MA, Skott M, Maltesen RG, Rasmussen BS, Nielsen S, Frøkiær J, Ring T & Wimmer R. (2019). Tissue, urine and blood metabolite signatures of chronic kidney disease in the 5/6 nephrectomy rat model. Metabolomics 15;112. doi.org/10.1007/s11306-019-1569-3.
INSTRUMENT(S): Bruker
SUBMITTER: Munsoor Hanifa
PROVIDER: MTBLS2052 | MetaboLights | 2020-11-16
REPOSITORIES: MetaboLights
Dataset's files
Items per page: 1 - 5 of 12 |
Publications
Tissue, urine and blood metabolite signatures of chronic kidney disease in the 5/6 nephrectomy rat model.
Metabolomics : Official journal of the Metabolomic Society 20190817 8
<h4>Introduction</h4>Progressive chronic kidney disease (CKD) is an important cause of morbidity and mortality. It has a long asymptomatic phase, where routine blood tests cannot identify early functional losses, and therefore identifying common mechanisms across the many etiologies is an important goal.<h4>Objectives</h4>Our aim was to characterize serum, urine and tissue (kidney, lung, heart, spleen and liver) metabolomics changes in a rat model of CKD.<h4>Methods</h4>A total of 17 male Wistar ...[more]
