Dataset Information

Metabolic Responses of a Model Green Microalga Euglena gracilis to Different Environmental Stresses

ABSTRACT:

Euglena gracilis, a green microalga known as a potential candidate for jet fuel producers and new functional food resources, is highly tolerant to antibiotics, heavy metals and other environmental stresses. Its cells contain many high-value products, including vitamins, amino acids, pigments, unsaturated fatty acids and carbohydrate paramylon as metabolites, which change contents in response to various extracellular environments. However, mechanism insights into the cellular metabolic response of Euglena to different toxic chemicals and adverse environmental stresses were very limited. We extensively investigated the changes of cell biomass, pigments, lipids and paramylon of E. gracilis under several environmental stresses, such as heavy metal CdCl₂, antibiotics paromomycin and nutrient deprivation. In addition, global metabolomics by ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) was applied to study other metabolites and potential regulatory mechanisms behind the differential accumulation of major high-valued metabolites. This study collects a comprehensive update on the biology of E. gracilis for various metabolic responses to stress conditions, and it will be of great value for Euglena cultivation and high-value [154 mm] [10 mm] Q7 metabolite production.

INSTRUMENT(S): Liquid Chromatography MS - negative - reverse phase, Liquid Chromatography MS - positive - reverse phase

SUBMITTER: Zixi Chen

PROVIDER: MTBLS2878 | MetaboLights | 2022-08-16

REPOSITORIES: MetaboLights

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Dataset's files

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			Action	DRS
	MTBLS2878	Other
	FILES	Other
	a_MTBLS2878_LC-MS_negative_reverse-phase_metabolite_profiling.txt	Txt
	a_MTBLS2878_LC-MS_positive_reverse-phase_metabolite_profiling.txt	Txt
	files-all.json	Other

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Publications

Metabolic Responses of a Model Green Microalga <i>Euglena gracilis</i> to Different Environmental Stresses.

He Jiayi J Liu ChenChen C Du Mengzhe M Zhou Xiyi X Hu Zhangli Z Lei Anping A Wang Jiangxin J

Frontiers in bioengineering and biotechnology 20210720

<i>Euglena gracilis</i>, a green microalga known as a potential candidate for jet fuel producers and new functional food resources, is highly tolerant to antibiotics, heavy metals, and other environmental stresses. Its cells contain many high-value products, including vitamins, amino acids, pigments, unsaturated fatty acids, and carbohydrate paramylon as metabolites, which change contents in response to various extracellular environments. However, mechanism insights into the cellular metabolic r ...[more]

PMID: 34354984

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