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Hirschprung Enterocolitis SCFA

ABSTRACT: Children with Hirschsprung disease (HD) who have a history of enterocolitis (HAEC) have a shift in colonic microbiota, many of which are necessary for short chain fatty acid (SCFA) production. As SCFAs play a critical role in colonic mucosal preservation, we hypothesized that fecal SCFA composition is altered in children with HAEC. Patients between age of 6 weeks and 16 years of age who were undergoing small bowel resection were selected, including those who were either receiving enteral nutrition preoperatively (control group), or those who were without enteral nutrition and receiving total parenteral nutrition (TPN group). At the time of operation, 100-500µl of effluent from the small bowel lumen was aspirated during the small bowel resection. The samples were immediately frozen in liquid nitrogen and stored at -80oC. Research is published: http://www.sciencedirect.com/science/article/pii/S0022346815006211

ORGANISM(S): Human Homo Sapiens

TISSUE(S): Feces

DISEASE(S): Enterocolitis

SUBMITTER: Maureen Kachman

PROVIDER: ST000189 | MetabolomicsWorkbench | Mon Jun 08 00:00:00 BST 2015

REPOSITORIES: MetabolomicsWorkbench

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