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H3K27M cells and glutamine metabolomics 1 million cell test (part-I)

ABSTRACT: Testing TCA concentrations of Diffuse Intrinsic Pontine Gliomas (DIPG) cellines with H3K27M mutations. One million cells are tested with a TCA concentrations panel. We are a high volume center for treating malignant gliomas, which gives us an advantage in obtaining tissue for these relatively rare tumors. We have developed several DIPG patient derived cell lines and xenografts that bear all the key molecular features of this disease including the H3K27M mutation and global H3K27 hypomethylation. These cells are low in passage and we think these lines more closely resemble the patients tumor pathology then established cell lines that have been in culture/mice for numerous years.

ORGANISM(S): Human Homo Sapiens

TISSUE(S): Glioma Cells

DISEASE(S): Cancer

SUBMITTER: David Daniels

PROVIDER: ST001023 | MetabolomicsWorkbench | Wed Jul 18 00:00:00 BST 2018

REPOSITORIES: MetabolomicsWorkbench

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