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Impact of genetic suppression (shRNA) of ALDH1A1 expression in human colon cancer cell line (COLO320)

ABSTRACT: Using a multi-omics approach, we have investigated the impact of genetic suppression (shRNA) of ALDH1A1 expression on transcriptomics, proteomics and untargeted metabolomics analyses in a human colon cancer cell line (COLO320). The present study (i) generates an integrative omic profile of scramble shRNA vs. ALDH1A1 shRNA COLO320 cells, and (ii) identifies possible alterations in biological pathways caused by suppression of ALDH1A1 expression.

ORGANISM(S): Human Homo Sapiens

TISSUE(S): Cultured Cells

DISEASE(S): Cancer

SUBMITTER: Vasilis Vasiliou

PROVIDER: ST001093 | MetabolomicsWorkbench | Mon Nov 12 00:00:00 GMT 2018

REPOSITORIES: MetabolomicsWorkbench

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