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Metabolomics of a Mouse Model for Retinitis Pigmentosa

ABSTRACT: Retinitis pigmentosa (RP) is a degenerative disease of the retina that affects approximately 1 million people worldwide. There are multiple genetic causes of this disease, for which, at present, there are no effective therapeutic strategies. We utilized broad spectrum metabolomics to identify perturbations in the metabolism of the rd10 mouse, a genetic model for RP. C57BL/6J and rd10 mice were raised in cyclic light followed by either light or dark adaptation at postnatal day (P) 18, an early stage in the degeneration process. Mice raised entirely in the dark until P18 were also evaluated. After euthanasia, retinas were removed and extracted for analysis by ultra-performance liquid chromatography-time of flight-mass spectrometry (UPLC-QTOF-MS).

ORGANISM(S): Mouse Mus Musculus

TISSUE(S): Eye Tissue

DISEASE(S): Eye Disease

SUBMITTER: Ellen Weiss

PROVIDER: ST001150 | MetabolomicsWorkbench | Mon Mar 18 00:00:00 GMT 2019

REPOSITORIES: MetabolomicsWorkbench

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