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Deep Metabolomics of a High-Grade Serous Ovarian Cancer Triple Knockout Mouse Model.

ABSTRACT: Metabolic alternations were investigated by applying Ultra Performance Liquid Chromatography Mass Spectrometry (UPLC-MS) to serum samples collected from triple knockout (TKO) mice at pre-malignant, early, and advanced stages of HGSC. Samples were analyzed with control mice, which have the same genetic background as TKO mice but develop no tumors. To enhance the selectivity for HGSC-specific metabolite markers, a tumor control group was also included. These were uterine tumor (UT) mice that developed uterine tumors, but no HGSC. All samples were analyzed using reverse phase (RP) and hydrophilic interaction liquid chromatography (HILIC) UPLC-MS analysis in positive and negative ion modes.

ORGANISM(S): Mouse Mus Musculus

TISSUE(S): Blood

DISEASE(S): Cancer

SUBMITTER: Danning Huang

PROVIDER: ST001172 | MetabolomicsWorkbench | Tue Apr 16 00:00:00 BST 2019

REPOSITORIES: MetabolomicsWorkbench

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