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The cecal and fecal metabolomes of horses before and after metronidazole administration

ABSTRACT: Metronidazole (15mg/kg BID PO) was given to horses (n=5) with in-dwelling cecal cannulas. The study was suspended after the fifth dose (day 3) due to adverse gastrointestinal effects. Cecal and fecal samples were obtained before and after (Days days -52, -28, -14, 0, 7, 14, 28 and 52) metronidazole administration. The metabolome was characterized by mass spectrometry-based methods. Fecal, but not cecal metabolites were affected by metronidazole. The fecal metabolites affected represented diverse metabolic pathways such as nucleic acid metabolism, secondary bile metabolism, fatty acid synthesis/degradation/elongation or metabolism and sugar metabolism.

ORGANISM(S): Horse Equus Caballus

TISSUE(S): Feces

SUBMITTER: Carolyn Arnold

PROVIDER: ST001248 | MetabolomicsWorkbench | Wed Sep 04 00:00:00 BST 2019

REPOSITORIES: MetabolomicsWorkbench

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