Metabolomics

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Dynamics of Exposure, Phthalates, and Asthma in a Randomized Trial (DEPART)


ABSTRACT: Project will investigate relationships between phthalate exposure, pediatric asthma health, and underlying biological pathways of toxicity among a rural, underserved Latino population located in Yakima Valley, WA. DEPART will benefit from the original study’s (HAPI’s) robust longitudinal repeat-measure design and community-engaged framework. DEPART will add new measurements including concentrations of urinary phthalate monoester metabolites and biomarkers of oxidative stress to better characterize exposure-response associations. This project’s primary goal is to deepen the understanding of pathophysiological phenomena underlying exposure-response relationships between phthalates and asthma health. Our specific aims are: (1) Characterize associations between urinary phthalate metabolite concentrations and short-term asthma morbidity, and (2) Determine individual relationships between urinary phthalate metabolite concentrations, short-term asthma morbidity, and biomarkers for oxidative stress to assess the potential for a mediating effect by oxidative stress. Covariates of interest will include atopic status, randomized intervention grouping, and the caregiver psychosocial stress assessment.

ORGANISM(S): Human Homo Sapiens

TISSUE(S): Urine

DISEASE(S): Environmental Exposure,Asthma

SUBMITTER: Douglas Walker  

PROVIDER: ST001317 | MetabolomicsWorkbench | Wed Feb 05 00:00:00 GMT 2020

REPOSITORIES: MetabolomicsWorkbench

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