Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Hepatocyte
DISEASE(S): Wounds And Injuries
SUBMITTER: Doeun Kim
LAB HEAD: Sangkyu Lee
PROVIDER: PXD018702 | Pride | 2021-09-09
REPOSITORIES: Pride
Action | DRS | |||
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Huh7_AMA_TMT_SET1_F1_500ng.raw | Raw | |||
Huh7_AMA_TMT_SET1_F2_500ng.raw | Raw | |||
Huh7_AMA_TMT_SET1_F3_500ng.raw | Raw | |||
Huh7_AMA_TMT_SET1_F4_500ng.raw | Raw | |||
Huh7_AMA_TMT_SET1_F5_500ng.raw | Raw |
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Toxins 20210309 3
Alpha-amanitin (α-AMA) is a cyclic peptide and one of the most lethal mushroom amatoxins found in <i>Amanita phalloides</i>. α-AMA is known to cause hepatotoxicity through RNA polymerase II inhibition, which acts in RNA and DNA translocation. To investigate the toxic signature of α-AMA beyond known mechanisms, we used quantitative nanoflow liquid chromatography-tandem mass spectrometry analysis coupled with tandem mass tag labeling to examine proteome dynamics in Huh-7 human hepatoma cells treat ...[more]