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Branched-chain alpha-ketoacids are preferentially reaminated and activate protein synthesis in the mouse heart

ABSTRACT: Branched-chain amino acids (BCAA) and their cognate α-ketoacids (BCKA) are elevated in an array of cardiometabolic diseases. Here we demonstrate that sequestration of BCAA and BCKA away from mitochondrial oxidation is likely due to low levels of expression of the mitochondrial BCAA transporter SLC25A44 in the heart, as its overexpression significantly lowers accumulation of [13C]-labeled valine from [U-13C]KIV.

ORGANISM(S): Mouse Mus Musculus

TISSUE(S): Heart

DISEASE(S): Obesity

SUBMITTER: Jacquelyn Walejko

PROVIDER: ST001666 | MetabolomicsWorkbench | Tue Jan 26 00:00:00 GMT 2021

REPOSITORIES: MetabolomicsWorkbench

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