Plasma metabolomics of diverse mouse strains infected with Plasmodium chabaudi
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ABSTRACT: To uncover links between metabolism and disease severity in murine malaria, we performed plasma metabolomics via Metabolon on eight inbred, Plasmodium chabaudi-infected mouse strains with diverse disease phenotypes. We sacrificed and collected plasma from >=3 mice per strain per day of acute infection alongside uninfected control mice (approximately days 5-12 depending on mouse strain). We collected disease severity data, e.g. weight loss, liver enzymes, and anemia, concurrently. Together, these data enable 1) a picture of strain-specific and conserved metabolic responses during acute malaria, and 2) a comparison between metabolic responses and disease severity.
ORGANISM(S): Mouse Mus Musculus
TISSUE(S): Blood
DISEASE(S): Malaria
SUBMITTER: David Schneider
PROVIDER: ST001775 | MetabolomicsWorkbench | Sun Apr 11 00:00:00 BST 2021
REPOSITORIES: MetabolomicsWorkbench
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