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Metabolomics of brown adipose tissue in murine heart failure model

ABSTRACT: Brown adipose tissue (BAT) was initially characterised as a thermogenic organ, and recent studies have suggested it plays a crucial role in maintaining systemic metabolic health. In this project, we demonstrated that alteration of BAT function contributes to development of heart failure through disorientation in choline metabolism. To analyze the changes of metabolites, we conducted the CE-TOF/MS analysis using BAT from TAC (thoracic aortic constriction) or sham-operated mice. In BAT from TAC-operated mice, we found increase of choline and glycerophosphorylcholine and a decrease of phosphorylcholine, suggesting that BAT dysfunction induces the disorientation of choline metabolism.

ORGANISM(S): Mouse Mus Musculus

TISSUE(S): Adipose Tissue

SUBMITTER: Yohko Yoshida

PROVIDER: ST001961 | MetabolomicsWorkbench | Wed Oct 13 00:00:00 BST 2021

REPOSITORIES: MetabolomicsWorkbench

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