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Lipidomics of brown adipocytes treated with d9-choline

ABSTRACT: Brown adipose tissue (BAT) was initially characterised as a thermogenic organ, and recent studies have suggested it plays a crucial role in maintaining systemic metabolic health. In this project, we demonstrated that alteration of BAT function contributes to development of heart failure through disorientation in choline metabolism. To analyze the detail effect of choline accumulation on brown adipocytes, we conducted the LC-QTOF/MS analysis using cultured brown adipocytes treated with d9-choline. In brown adipocytes treated with d9-choline, we found increase of phosphatidylcholine and lysophosphatidylcholine, suggesting that choline was metabolized in healthy brown adipocytes.

ORGANISM(S): Mouse Mus Musculus

TISSUE(S): Adipose Tissue

SUBMITTER: Yohko Yoshida

PROVIDER: ST001960 | MetabolomicsWorkbench | Thu Oct 14 00:00:00 BST 2021

REPOSITORIES: MetabolomicsWorkbench

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