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The interaction of ceramide-1-phosphate with group IVA cytosolic phospholipase A2 modulates neutrophil polarization during inflammatory responses

ABSTRACT: Bone marrow-derived mouse neutrophils from wildtype, cPLA2alpha-knockin (interaction site on cPLA2alpha for its substrate C1P was ablated), and cPLA2alpha-knockout (cPLA2alpha gene mutated) mice were exposed to 4 hours of trans-endothelial migration and resulting eicosanoids were analyzed (eg, PGE2, PGD2, 5-HETE, and 5-oxo-ETE).

ORGANISM(S): Mouse Mus Musculus

TISSUE(S): Bone Marrow

DISEASE(S): Inflammation

SUBMITTER: Kenneth Maus

PROVIDER: ST002445 | MetabolomicsWorkbench | Mon Jan 16 00:00:00 GMT 2023

REPOSITORIES: MetabolomicsWorkbench

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The interaction of ceramide-1-phosphate with group IVA cytosolic phospholipase A2 modulates neutrophil polarization during inflammatory responses

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