Metabolomics

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Six tryptophan metabolites in mouse serum


ABSTRACT: We establish that six tryptophan metabolites are essentially not CYP1A1 substrates and the level of these metabolite in mouse serum are not affected by a lack of CYP1A1 or any other Aryl hydrocarbon Receptor (AHR) dependent metabolic pathway expression in vivo. These results establish that tryptophan metabolites that circulate at significant levels in vivo are not subject to an autoregulatory feedback loop between the AHR and CYP1A1.

ORGANISM(S): Mouse Mus Musculus

TISSUE(S): Blood

SUBMITTER: Fancong Dong  

PROVIDER: ST002491 | MetabolomicsWorkbench | Wed Feb 22 00:00:00 GMT 2023

REPOSITORIES: MetabolomicsWorkbench

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