Project description:Age-related variation of bacterial and fungal communities in different body habitats across the young, elderly and centenarians in Sardinia
Project description:Characterization of body location-specific hair proteomic variation and its effect on the identification of genetically variant peptide markers for protein-based human identification. LLNL-MI-756827
Project description:Interventions: 1. Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS);
2. Colonoscopy.
Primary outcome(s): Investigate whether DWIBS is effective for colorectal cancer screening.
Study Design: N/A: single arm study, Single blinded (masking used), N/A , unknown, Crossover
Project description:Fibroblasts are the principal stromal cells that exist in whole organs and play vital roles in many biological processes. Although the functional diversity of fibroblasts has been estimated, a comprehensive analysis of fibroblasts from the whole body has not been performed and their phenotypical diversity has not been sufficiently explored. The aim of this study was to elucidate the phenotypical diversity of human fibroblasts within the whole body. Global gene expression analysis of 63 human primary fibroblasts from 13 organs elucidated that fibroblasts from the gastrointestinal tract showed a remarkably distinct character compared to that seen in other organs. Furthermore, gastrointestinal fibroblasts were created by topologically diverse subgroups of fibroblasts depending on their organ and histoanatomical site in the gastrointestinal walls.
Project description:We used isotopic (heavy) labelling to delineate between female and male proteins interacting in the female reproductive tract. Here, we test the efficiency of the labelling protocols on the whole body of males and females.
