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DNA sequence reads from an ancient Egyptian emmer wheat sample

ABSTRACT: Whole genome sequence from 3,000-year-old Egyptian emmer wheat reveals dispersal and domestication history

PROVIDER: PRJEB31103 | ENA |

REPOSITORIES: ENA

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Ritual revealed: psychotropic substances in a Ptolemaic Egyptian vase

Project description:LC-MS/MS-based Proteomic analysis of an archaeological Ptolemaic Egyptian vase. Other complementary analyses performed: aDNA on chloroplasts, metabolomics LC-MS/MS, SR-FTIR microscopy, SR-XRD.

2024-02-26 | PXD040739 | Pride

Different Egyptian rousette interferon omega proteins elicit an overlapping but not identical transcriptional response in bat cells.

Project description:Abstract from accompanying publication: "Bats host a number of viruses that cause severe disease in humans without experiencing overt symptoms of disease themselves. While the mechanisms underlying this ability to avoid sickness are not known, deep sequencing studies of bat genomes have uncovered genetic adaptations that may have functional importance in the antiviral response of these animals. Egyptian rousette bats (Rousettus aegyptiacus) are the natural reservoir hosts of Marburg virus (MARV). In contrast to humans, these bats do not become sick when infected with MARV. A striking difference to the human genome is that Egyptian rousettes have an expanded repertoire of IFNW genes. To probe the biological implications of this expansion, we synthesized IFN-ω4 and IFN-ω9 proteins and tested their antiviral activity in Egyptian rousette cells. Both IFN-ω4 and IFN-ω9 showed antiviral activity against RNA viruses, including MARV, with IFN-ω9 being more efficient than IFN-ω4. Using RNA-Seq, we examined the transcriptional response induced by each protein. Although the sets of genes induced by the two IFNs were largely overlapping, IFN-ω9 induced a more rapid and intense response than did IFN-ω4. About 13% of genes induced by IFN-ω treatment are not found in the Interferome or other ISG databases, indicating that they may be uniquely IFN-responsive in this bat."

2020-03-16 | GSE145761 | GEO

Landscape and age dynamics of immune cells in the Egyptian Rousette Bat

Project description:Bats harbor high-impact zoonotic viruses in absence of clinical disease, which has been recently associated with unique features of their immune system. They seem to restrict inflammation and possibly limit disease manifestation to a minimum. In-depth characterization of cellular immunity in bats is yet largely missing, and imprinting of age and development on immune cell compartments remains unexplored. We employed single-cell transcriptomics and established immunostaining panels to investigate the immune cell populations peripheral blood for juvenile and adult Egyptian Rousette bats (ERB).

2022-07-21 | GSE183925 | GEO

Metagenomic analysis of Egyptian mummies

Project description:Metagenomic analysis of Egyptian mummies.

| PRJEB33848 | ENA

Ancient Egyptian herbal wines.

Project description:Chemical analyses of ancient organics absorbed into pottery jars from the beginning of advanced ancient Egyptian culture, ca. 3150 B.C., and continuing for millennia have revealed that a range of natural products--specifically, herbs and tree resins--were dispensed by grape wine. These findings provide chemical evidence for ancient Egyptian organic medicinal remedies, previously only ambiguously documented in medical papyri dating back to ca. 1850 B.C. They illustrate how humans around the world, probably for millions of years, have exploited their natural environments for effective plant remedies, whose active compounds have recently begun to be isolated by modern analytical techniques.

| S-EPMC2678600 | biostudies-literature

Ancient DNA of Mongolia and Inner Asia

Project description:A dynamic 6,000-year genetic history of Eurasia's Eastern Steppe

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The contents of unlabelled Ancient Roman and Egyptian amphoras

Project description:The contents of unlabelled Ancient Roman and Egyptian amphoras reflect the smaller scale local transit of secondary domestic cargoes

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Genotyping-by-sequencing (GBS) of wild and cultivated Lens accessions and the domestication history of lentils

Project description:To use NGS data to investigate the history of lentil domestication.

2020-09-30 | E-MTAB-9222 | biostudies-arrayexpress

Ancient transposable elements transformed the uterine regulatory landscape and transcriptome during the evolution of mammalian pregnancy

Project description:A major challenge in biology is to determine how evolutionarily novel characters originate, however, mechanistic explanations for the origin of novelties are almost completely unknown. The evolution of mammalianM-BM- pregnancy is an excellent system in which to study the origin of novelties because extant mammals preserve major stages in the transition from egg-laying to live-birth. To determine the molecular bases of this transition we characterized the pregnant/gravid uterine transcriptome from tetrapods, including species in the three major mammalian lineages, and used ancestral transcriptome reconstruction to trace the evolutionary history of uterine gene expression. We show that thousands of genes evolved endometrial expression during the origins of mammalian pregnancy, including numerous genes that mediate maternal-fetal communication and immunotolerance.Furthermore we show that thousands of regulatory elements active inM-BM- decidualized human endometrial stromal cellsM-BM- are derived from ancient mammalian transposable elements which provided binding sites for transcription factors that mediate decidualization and endometrial cell-type identity.M-BM- Our results indicate that one of the defining mammalian novelties evolved via domestication of ancient mammalian transposable elements into hormone-responsive regulatory elements throughout the genome. Examination of histone modification and DNAse hypersensitivity in decidualized dESC

2015-01-30 | E-GEOD-61793 | biostudies-arrayexpress

Five Wheat Species Flour Proteomics by LC-MS/MS

Project description:LC-MS/MS-based LFQ proteomics of 150 wheat full-kernel flours from five different wheat species (common wheat, spelt, durum wheat, emmer, einkorn) grown at three different locations.

2023-03-30 | PXD028676 | Pride

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