Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

G9a inhibition in LAN-1 neuroblastoma cells

ABSTRACT: RNA-seq analysis of LAN-1 neuroblastoma cells treated with G9a inhibitor BIX-01294.

PROVIDER: PRJEB35417 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

G9a-dependent gene expression in mouse AML cells

2014-01-08 | GSE53894 | GEO

G9a-dependent gene expression in mouse AML cells

Project description:The methyltransferase G9a was found to play a role in the disease progression of a murine model of AML. Mouse HSPCs were transformed with HoxA9/Meis1 and treated with G9a/GLP inhibitor UNC0638. We used microarrays to detail the global program of gene expression that depends on the methyltransferase activity of G9a in murine AML cells.

2014-01-08 | E-GEOD-53894 | biostudies-arrayexpress

Chromatin profiling following SWI/SNF inhibition in neuroblastoma cells [ChIP-seq]

Project description:To assess the genome-wide effects of SWI/SNF activity in MYCN-amplified neuroblastoma cells, we performed ChIP-seq in IMR-32 cells treated with either DMSO or the SWI/SNF inhibitor BRM014. Pronounced loss of chromatin occupancy was observed for members of the neuroblastoma core regulatory circuitry within 1 hour.

2023-10-24 | GSE206310 | GEO

LAN - FCE018

Project description:LAN - FCE018 Metagenome

| PRJNA693281 | ENA

HDAC inhibition suppresses telomerase activity in neuroblastoma cells harboring TERT rearrangements [array]

Project description:Genome wide DNA methylation profiling of high-risk TERT-rearranged neuroblastoma cells treated with solvent or HDAC inhibitor panobinostat. The Illumina HumanMethylation EPIC Beadchip was used to obtain DNA methylation profiles. Samples included 3 solvent treated samples and 3 panobinostat-treated samples after 18 h of treatment.

2022-08-04 | GSE155703 | GEO

Inhibition of H3K9me2-specific histone methyltransferase, G9a/GLP, reveals transcripts regulated by the establishment of H3K9me2 in hematopoietic stem and progenitor cells

Project description:We have performed RNA-seq from DMSO control treated, G9a/GLP inhibitor (UNC0638) treated, and DNA-demethylating agent (Decitabine) treated CD34+ hematopoietic stem and progenitor cells. This experiment was performed to identify transcripts that were uniquely affected by the loss of H3K9me2 in hematopoietic stem and progenitor cells.

2023-05-01 | GSE204743 | GEO

Expression profiling tumor cells from MYCN-driven neuroblastoma upon BRD4 or AURKA inhibition

Project description:Amplification of MYCN is the most prominent genetic marker of high-stage neuroblastoma, a childhood tumor originating from the neural crest. We generated a cell line (mNB-A1) from tumors developed in transgenic mouse and treated these cells with DMSO (n=6), the BRD4-inhibitor JQ1 (n=3) or the AURKA-inhibitor MLN8237 (n=3) for 24 h. The expression profiles of vehicle (DMSO)-treated mNB-A1 cells were compared to JQ1- or MLN8237-treated mNB-A1 cells.

2014-09-01 | E-GEOD-57810 | biostudies-arrayexpress

Methylation map of 8 neuroblastoma cell lines: NGS after MBD2-capture

Project description:8 neuroblastoma (NB) cell lines (CLB-GA, IMR-32, SH-SY5Y, N206, CHP-902R, LAN-2, SK-N-AS, SJNB-1) their methylome is determined by sequencing after MBD2-capture using MethylCollector (ActiveMotif)

2012-09-13 | GSE31353 | GEO

Expression profiling of tumor cells from MYCN-driven neuroblastoma upon BRD4 or AURKA inhibition

2014-09-01 | GSE57810 | GEO

Inhibition of a G9a/DNMT network triggers an immune-mediated bladder cancer regression treated with CM272 (IC50)

Project description:Based on the identification of G9a as a potential target in BC, we decided to test the effect of a recently described dual inhibitor against G9a/DNMTs, CM-272, in several BC cell lines

2019-02-01 | GSE115544 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data