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Bifidobacterium bifidum suppresses antibiotic-induced inflammation

ABSTRACT: Bifidobacterium bifidum suppresses gut inflammation caused by repeated antibiotic disturbance without recovering gut microbiome diversity in mice

PROVIDER: PRJEB36500 | ENA |

REPOSITORIES: ENA

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Bifidobacterium bifidum BF-1 Suppresses Helicobacter pylori-Induced genes in Human Epithelial Cells

Project description:We have shown that pre-incubation with Bifidobacterium bifidum (B. bifidum) strain BF-1, a probiotic strain known to improve H. pylori-associated gastritis, suppresses the induction of IL-8 by the pathogen. To investigate how BF-1 affects gene expression in H. pylori-infected cells, we performed microarray analysis to assess gene expression in epithelial cells, which had been pre-incubated with BF-1 and infected with H. pylori. Four-condition experiment. Biological replicates with a dye-exchange experiment. Biological replicates with a longer incubation time experiment.

2010-10-13 | E-GEOD-20171 | biostudies-arrayexpress

Bifidobacterium bifidum BF-1 Suppresses Helicobacter pylori-Induced genes in Human Epithelial Cells

2010-10-13 | GSE20171 | GEO

Functional genomic analyses of Bifidobacterium bifidum PRL2010 highlight how this microorganism interact with the human host

Project description:Bifidobacteria represents one of the dominant group of microorganisms colonizing the intestine of infants. However, the genetic determinants supporting the establishment and the interaction with the human hosts are still largely unknown. Most commensal bacteria interacting with eukaryotic hosts express adhesive molecules on their surfaces that modulate interaction with host cell receptors or with soluble macromolecules. Whole genome transcription profiling of B. bifidum PRL2010, a strain isolated from infant stool, under in vitro as well as in vivo conditions revealed the expression of few common extracellular proteins among which type 1 pili encoding genes. To investigate the molecular mechanisms sustaining the interaction of PRL2010 strain with the human gut, we first explored the global genome transcription profiling of this strain in a in vitro human model such as in the presence of HT29 cell lines. The transcriptome was analyzed using a custom B. bifidum PRL2010 array representing the 90% of this organismM-bM-^@M-^Ys protein coding genes. To better evaluate the conserved responses by B. bifidum, the in vivo transcriptomes were quantified against a diverse set of transcriptome patterns identified for in vitro laboratory cultures of the strain, i.e., B. bifidum responses after growth on an cellM-bM-^@M-^Ys monolayers growth medium (DMEM); B.bifidum responses after growth on synthetic medium (MRS). Briefly, we analized five conditions, two of which are also used as references. Every experiment was performed in duplicate and in vivo condition was performed in quadruplicate.

2013-07-01 | E-GEOD-36442 | biostudies-arrayexpress

Bifidobacterium bifidum

Project description:Bifidobacterium bifidum pangenome

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Effects of Bifidobacterium bifidum PRL2010 on gene expression in intestinal epithelial cells

2010-10-01 | GSE21976 | GEO

Bifidobacterium bifidum

Project description:Bifidobacterium bifidum Genome sequencing

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Bifidobacterium bifidum PRL2010 actively changes the expression profiles of mouse

Project description:We studied the global transcription profiling of mouse upon colonization with Bifidobacterium bifidum PRL2010 by using DNA microarrays.

2013-11-19 | GSE48495 | GEO

Effects of housekeeping sortase disruption on Bifidibacterium bifidum toranscriptome

Project description:To explore the molecular mechanism of B. bifidum adhesion, we compared transcriptomes among WT and non-adhesive mutants cultured in MRS or m-ILS medium.

2021-11-01 | GSE175843 | GEO

Effects of Bifidobacterium bifidum PRL2010 on gene expression in intestinal epithelial cells

Project description:Analysis of gene expression in Caco-2 intestinal epithelial cells stimulated with Bifidobacterium bifidum PRL2010. We used microarrays to investigate gene expression in intestinal epithelial cells in response to Bifidobacterium bifidum PRL2010, in particular genes involved in mucin pathways. Caco-2 cells were grown in transwell plates to 4 days post-confluence. Cells were then incubated for 2h and 4h with Bifidobacterium bifidum PRL2010. The experiment was performed in duplicate. Caco-2 RNA was extracted and hybridized to Affymetrix NuGO_Hs1a52018 arrays.

2010-10-01 | E-GEOD-21976 | biostudies-arrayexpress

Bifidobacterium bifidum PRL2010 actively changes the expression profiles of human cell lines

Project description:We studied the global transcription profiling of human cell lines upon colonization with Bifidobacterium bifidum PRL2010 by using DNA microarrays.

2013-11-19 | GSE48494 | GEO

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