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Fossil metagenome

ABSTRACT: Genome-wide comparison of medieval and modern Mycobacterium leprae

PROVIDER: PRJNA200950 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6233936_1.fastq.gz	Fastqsanger.gz
	SRR6233936_2.fastq.gz	Fastqsanger.gz
	SRR847034_1.fastq.gz	Fastqsanger.gz
	SRR847034_2.fastq.gz	Fastqsanger.gz
	SRR847035_1.fastq.gz	Fastqsanger.gz

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Project description:Genome-wide analysis of medieval Mycobacterium leprae and human samples

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Project description:To this date, host transcriptome studies in leprosy have focused on Schwann cells, as well as mouse-footpad and skin biopsies. Despite macrophages being the most infected cell types in leprosy lesions, there is no genome-wide experiments with this model. Here, we aimed at identifying host macrophages transcriptional changes induced by live-Mycobacterium leprae infection for 48 hours.

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Bannerman2022 Whole Genome Metabolism - Mycobacterium leprae (strain Br4923)_1

Project description:This is a whole genome metabolism model of Mycobacterium leprae

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Profiling of Gene expression in Mycobacterium leprae (M. leprae)-infected footpad of BALB/c nu/nu mice

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Modern and Fossil Coral Skeletal Proteomes - Fossil Soluble Trypsin1

Project description:Here we report the first recovery, sequencing, and identification of fossil biomineral proteins from a Pleistocene invertebrate. Fossils of the Caribbean stony coral Orbicella annularis retain total hydrolyzable amino acids of a similar composition to extracts from modern O. annularis skeletons and ~10% of the modern skeletal proteome was sequenced by LC-MS/MS over multiple trials in the best-preserved fossil coral specimen. The data are rich in acidic amino acids such as aspartate and glutamate typical of skeletal proteins, and one of the four sequenced fossil proteins, a highly acidic protein, has been previously characterized in modern coral skeletons. A combination of degradation, or amino acid racemization inhibition of trypsin digestion, appears to limit greater recovery. Nevertheless, our workflow determines optimal samples for effective sequencing of fossil coral proteins, allowing comparison of modern and fossil invertebrate protein sequences, and will likely lead to further improvements of the methods. Sequencing of endogenous organic mand biotic responses to paleoenvironments.

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