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GE/miRNA expression profile of PBMCs in healthy subjects and MS patients after extra virgin olive oil (EVOO) intake

ABSTRACT: GE/miRNA expression profile of PBMCs in healthy subjects and MS patients after extra virgin olive oil (EVOO) intake

PROVIDER: PRJNA302256 | ENA |

REPOSITORIES: ENA

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GE expression profile of PBMCs in healthy subjects and MS patients after extra virgin olive oil (EVOO) intake - PART 3 - MS Patients

2016-07-19 | GSE84591 | GEO

GE expression profile of PBMCs in healthy subjects and MS patients after extra virgin olive oil (EVOO) intake - PART 3 - MS Patients

Project description:Gene expression profiles of PBMCs in patients with MS following extra virgin olive oil intake. The aim of the present study was to investigate the whole-genome gene and miRNA profiles of after EVOO intake. Results provide the information of changes in PBMCs transcriptome following EVOO intake. RNA obtained from PBMCs of the same patients before and after extra virgin olive oil intake (paired samples). Comparisons: T0 vs. T1 (paired samples)

2016-07-19 | E-GEOD-84591 | biostudies-arrayexpress

miRNA expression profile of PBMCs in healthy subjects after extra virgin olive oil (EVOO) intake - Part 2 (Controls)

2016-07-19 | GSE75026 | GEO

miRNA expression profile of PBMCs in healthy subjects after extra virgin olive oil (EVOO) intake - Part 2 (Controls)

Project description:miRNA expression profiles of PBMCs in healthy subjects following extra virgin olive oil intake. The aim of the present study was to investigate the whole-genome gene and miRNA profiles of PBMCs after EVOO intake. Results provide the information of changes in PBMPs transcriptome following EVOO intake. RNA obtained from PBMCs of the same patients before and after extra virgin olive oil intake (paired samples). Comparisons: T0 vs. T1 (paired samples) - Controls

2016-07-19 | E-GEOD-75026 | biostudies-arrayexpress

Gene expression profile of PBMCs in healthy subjects and MS Patients after extra virgin olive oil (EVOO) intake - Part 1 (Controls)

2016-07-19 | GSE75025 | GEO

Gene expression profile of PBMCs in healthy subjects and MS Patients after extra virgin olive oil (EVOO) intake - Part 1 (Controls)

Project description:Gene expression profiles of PBMCs in healthy subjects following extra virgin olive oil intake. The aim of the present study was to investigate the whole-genome gene and miRNA profiles of after EVOO intake. Results provide the information of changes in PBMPs transcriptome following EVOO intake. RNA obtained from PBMCs of the same subjects before and after extra virgin olive oil intake (paired samples). Comparisons: T0 vs. T1 (paired samples) - Controls

2016-07-19 | E-GEOD-75025 | biostudies-arrayexpress

Transcription profiling of colon mucosa from HLAB27 transgenic rats fed extra-virgin olive oil rich in polyphenols

Project description:HLA-B27 transgenic rats, experimental model of chronic colitis, fed with a diet in which the lipid component was provided by corn oil (CO group), extra-virgin olive oil rich in phenols, 718.8 mg of total phenols/kg of olive oil (EVOO group) or the same extra-virgin olive oil, deprived of phenolic compounds but retaining other minor components such as a-tocopherol (ROO group).

2018-11-26 | E-MTAB-6218 | biostudies-arrayexpress

Olive oil phenols and GE in the aging mouse brain

Project description:The aim of this study was to evaluate whether the dietary treatment with olive oil phenols modifies the profile of microRNA and gene expression in different areas of the aging mouse brain and to correlate these changes with the cognitive and motor changes observed in the same aging animals. C57Bl/6J mice were fed from middle age to senescence with extra-virgin olive oil (10% wt/wt dry diet) rich in polyphenols (H-EVOO group, total polyphenol dose/day, 6mg/kg) or with the same extra-virgin olive oil deprived of phenolic compounds (L-EVOO group). By whole gene expression analysis we identified 53 genes differentially expressed in the cortex of H-EVOO mice compared to L-EVOO mice and no genes differentially expressed in the cerebellum. Gene Set Expression analysis (GSEA) found 6 gene sets significantly modulated by the dietary treatments in cortex, like the agrin-related postsynaptic differentiation gene set, involved in cholinergic synaptic differentiation and maintenance, exerting effects on axonal and dendritic growth. miRNA profiling found only 6 miRNA differentially modulated after 12 months of feeding and 63 after six months. Among them we noted miRNAs previously associated to neurodegenerative disorders such as mir101, 8.5 time more expressed in the cortex of L-EVOO fed mice compared to the H-EVOO group and no expressed in young mice. We extended our analysis on cortex harvested from transgenic TgCRND8 mice, a model of Alzheimer's disease, observing an overall down-regulation of miRNAs compared to mice of the same age. On the contrary, the H-EVOO fed mice cortex showed expression profiles similar to those of young mice, results supporting our previous data demonstrating that extra virgin olive oil rich in polyphenols may improve some age-related dysfunctions.

2013-09-10 | E-MTAB-1530 | biostudies-arrayexpress

GE/miRNA expression profile of PBMCs in healthy subjects and MS patients after extra virgin olive oil (EVOO) intake

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-07-19 | GSE75027 | GEO

Proteomics of extra virgin olive oil (EVOO)

Project description:Proteins and peptides are minor components of vegetal oils. The presence of these compounds in virgin olive oil was first reported in 2001, but the nature of the olive oil proteome is still a puzzling question for food science researchers. In this project, we have compiled for a first time a comprehensive proteomic dataset of olive fruit and fungal proteins that are present at low but measurable concentrations in a vegetable oil from a crop of great agronomical relevance as olive (Olea europaea L.). Accurate mass nLC-MS data were collected in high definition direct data analysis (HD-DDA) mode using the ion mobility separation step. Protein identification was performed using the Mascot Server v2.2.07 software (Matrix Science) against an ad hoc database made of olive protein entries. Starting from this proteomic record, the impact of these proteins on olive oil stability and quality could be tested. Moreover, the effect of olive oil proteins on human health and their potential use as functional food components could be also evaluated. In addition, this dataset provides a resource for use in further functional comparisons across other vegetable oils, and also expands the proteomic resources to non-model species, thus also allowing further comparative inter-species studies.

2020-09-29 | PXD019894 | Pride

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