Project description:This study examined the proteome profile in the hippocampus, medial prefrontal cortex, and striatum of APPswe/PS1dE9 transgenic mice (APP/PS1) model of Alzheimer’s disease compared to wild-type mice. The effect of tocotrienol-rich fraction (TRF), a mixture of vitamin E analogs derived from palm oil supplementation on the proteome profile of APP/PS1 mice hippocampus, medial prefrontal cortex, and striatum was also investigated. The analysis was performed using ultrahigh-performance liquid chromatography coupled with Q Exactive HF Orbitrap mass spectrometry. This study was in hoped to understand the mechanisms of Alzheimer’s disease at proteome level, and pre-emptive activity of TRF to combat the disease.
Project description:To describe the protein profile in hippocampus, colon and ileum tissue’ changing after the old faeces transplants, we adopted a quantitative label free proteomics approach.
Project description:Microarrays has been used to analyze the effect of voluntary wheel running in the SAMP8 mice using the SAMR1 mouse strain as control. Cortex gene expresion of SAMP8 which have been resting or exercising and SAMR1 sedentary.
Project description:Gene expression profiling reveals neuroprotective and antiinflammatory effects of TG in SAMP8 (aging model ) mice Hippocampus thus helps in acelerating learning and memory restoration process. by suppressing proinflammatory cytokine related genes and thus accekerate neurotransmitter release in SAMP8 aging model mice hippocampus
