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NHP gene expression after 4 Gy total body irradiation.

ABSTRACT: NHP gene expression after 4 Gy total body irradiation.

PROVIDER: PRJNA451211 | ENA |

REPOSITORIES: ENA

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NHP gene expression after 4 Gy total body irradiation.

Project description:In the current study, we investigated the gene expression response of blood cells of non-human primates that were total body irradiated with a 4 Gy dose. We isolated total RNA from peripheral blood at 3 days before irradiation, and then from the same animals on days 3, 5 and 7 days after irradiation. Using Agilent Rhesus microarrays, we identified genes that were significantly differentially expressed across the 7-day time course of this study. We identified common biological functions affected that persisted across the 7-day study.

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Mouse bone marrow stromal cells: before or after total body irradiation

Project description:Comprehensive gene expression analysis in BM-resident stromal cells was performed for an overview of BM environmental change caused by total body irradiation (TBI). Total RNA samples collected from BM-resident stromal cells with or without TBI were subjected to high sensitivity DNA microarray assays Three-condition experiment: Unirradiated, 1 day after TBI and 3 days after TBI. Bone marrow stromal cells were obtained from C57BL/6 mice (n = 6) either non-irradiated or after 9.5 Gy irradiation at indicated times.

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