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Regulating stem cell-related genes induces the plastic differentiation of cancer stem cells to treat cancer [in vitro]

ABSTRACT: Regulating stem cell-related genes induces the plastic differentiation of cancer stem cells to treat cancer [in vitro]

PROVIDER: PRJNA476108 | ENA |

REPOSITORIES: ENA

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Regulating stem cell-related genes induces the plastic differentiation of cancer stem cells to treat cancer

Project description:Regulating stem cell-related genes induces the plastic differentiation of cancer stem cells to treat cancer

| PRJNA476106 | ENA

Regulating stem cell-related genes induces the plastic differentiation of cancer stem cells to treat cancer [in vivo]

Project description:Relapse of cancer is associated with multi-directional differentiation, and unrestricted proliferative replication potential of cancer stem cells. Herein, we propose the plastic differentiation strategy for irreversible differentiation of cancer stem cells. Whole gene expression analysis revealed that salinomycin induced the cancer stem cells into normal cells, dormant cells, and mature cancer cells. Besides, the results indicated that the gatekeeper was related to the inhibition of PKC α signaling pathway. The differentiated normal or dormant cells were incorporated into normal tissue, while the rest were killed by chemotherapy. Our findings would offer the evidence for plastic differentiation of cancer stem cells, and propose an invert strategy for cancer therapy.

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Regulating stem cell-related genes induces the plastic differentiation of cancer stem cells to treat cancer [in vitro]

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Project description:Regulating stem cell-related genes induces the plastic differentiation of cancer stem cells to treat cancer [in vivo]

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Regulating Stem Cell-Related Genes Induces the Plastic Differentiation of Cancer Stem Cells to Treat Breast Cancer.

Project description:Relapse of cancer is associated with multidirectional differentiation and unrestricted proliferative replication potential of cancer stem cells. Herein, we propose the plastic differentiation strategy for irreversible differentiation of cancer stem cells; further, salinomycin and its newly constructed functional liposomes are used to implement this strategy. Whole gene, cancer stem cell-related RNA, and protein expression analyses reveal that salinomycin induces the cancer stem cells into normal cells, dormant cells, and mature cancer cells. Besides, the results indicate that the gatekeeper is related to the inhibition of the protein kinase C (PKC) α signaling pathway. The differentiated normal or dormant cells are incorporated into normal tissue, whereas the rest are killed by chemotherapy. The findings would offer the evidence for plastic differentiation of cancer stem cells and propose a novel strategy for cancer therapy.

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