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Micro-RNA expression profiles in upper tract urothelial carcinoma differentiate stage and tumor progression: secondary data set

ABSTRACT: Micro-RNA expression profiles in upper tract urothelial carcinoma differentiate stage and tumor progression: secondary data set

PROVIDER: PRJNA490640 | ENA |

REPOSITORIES: ENA

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Micro-RNA expression profiles in upper tract urothelial carcinoma differentiate stage and tumor progression: secondary data set

Project description:Accurate grading and staging of upper tract urothelial carcinoma (UTUC) often proves challenging, and improved knowledge of tumor biology could identify patients who are candidates for minimally invasive therapy rather than nephroureterectomy (NU). Total RNA was extracted from formalin-fixed, paraffin-embedded NU samples. Thirty-five samples with diverse pathologies were selected and screened via microRNA RT-qPCR array for 752 unique miRNA. Validation of differentially expressed miRNA was performed on 123 additional NU tissue specimens from two institutions. The data presented in this series are for the 123 samples analyzed in the validation analysis. The data were normalized to the average of the insignificant control miRNA detected in all samples: miR-125b-5p and miR-185-5p, which were selected from the screening array dataset using NormFinder©.

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Micro-RNA expression profiles in upper tract urothelial carcinoma differentiate stage and tumor progression

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