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BMP9 signaling promotes the normalization of tumor blood vessels

ABSTRACT: BMP9 signaling promotes the normalization of tumor blood vessels

PROVIDER: PRJNA603196 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10965044.fastq.gz	Fastqsanger.gz
	SRR10965045.fastq.gz	Fastqsanger.gz
	SRR10965046.fastq.gz	Fastqsanger.gz
	SRR10965047.fastq.gz	Fastqsanger.gz
	SRR10965048.fastq.gz	Fastqsanger.gz

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BMP9 signaling promotes the normalization of tumor blood vessels

Project description:We sought to evaluate the effects of BMP9 on tumor vascular formation. We observed that BMP9 promotes vascular normalization with decreased permeability and increased perfusion and perivascular cell coverage. Gene expression analysis of CD31-positive cells isolated from control and BMP9-overexpressing tumors revealed enrichment of pathways involved in Notch signaling and vascular quiescence.

2020-01-26 | GSE144256 | GEO

Pro-BMP9 and sENG monomer:BMP9 complex signalling in human pulmonary arterial endothelial cells after 1.5 hours treatment

Project description:This experiment was desinged to investigate the difference in global gene expression induced by the circulating form of BMP9, pro-BMP9, and BMP9 in complex with soluble endoglin (sENG:BMP9).

2019-09-23 | GSE119206 | GEO

Gene expression profiling in PA1 ovarian cancer cells under anchorage independence either in the presence of vehicle or BMP9 treatment for 24 hours

Project description:BMP9 promotes anoikis sensitivity in cancer cell lines. Here we examine the changes in gene expression in response to BMP9 in cells under anoikis to identify potential pathways associated with anoikis sensitivity.

2022-07-26 | GSE185924 | GEO

Expression profiling of BMP9-stimulated mesenchymal stem cells

Project description:To identify potential target genes regulated by BMP9 in MSCs, we used microarray to profile expression patterns of BMP9- vs. GFP-stimulated MSCs.

2013-07-16 | GSE48882 | GEO

Expression profiling of BMP9-stimulated mesenchymal stem cells

Project description:To identify potential target genes regulated by BMP9 in MSCs, we used microarray to profile expression patterns of BMP9- vs. GFP-stimulated MSCs. Subconfluent mouse C3H10T1/2 cells were transduced with adenoviral vector expressing BMP9 or GFP for 30h. Total RNA was isolated for microarray analysis using Affymetrix mouse MOE430A GeneChips. Experiments were done in triplicate.

2013-07-16 | E-GEOD-48882 | biostudies-arrayexpress

Transcriptional profiling of mouse aorta after deletion of BMP9 and BMP10

Project description:Aorta was isolated from ANF-Cre positive/BMP10 loxP/loxP/BMP9-/- (BMP9/10 dKO) mice. ANF-Cre negative BMP10 loxP/loxP mice were used as controls. Transcritional profiling was performed to understand the impact of BMP9/10 expression on aorta function.

2021-02-05 | GSE160026 | GEO

Transcriptional profiling of mouse aorta after deletion of BMP9 and BMP10.

Project description:Aorta was isolated from ANF-Cre positive / BMP10 loxP/loxP / BMP9-/- (BMP9/10 dKO) mice. ANF-Cre negative BMP10 loxP/loxP mice were used as controls. Transcriptional profiling was performed to understand the importance of BMP9/10 expression on aorta function.

2020-10-30 | E-MTAB-8914 | biostudies-arrayexpress

Pro-BMP9 and pro-BMP10 signalling in pulmonary arterial endothelial cells

Project description:This study was designed to compare the global gene expression change induced by the circulating, prodomain bound forms of BMP9 and BMP10 (pro-BMP9 and pro-BMP10) in human pulmonary arterial endothelial cells (PAECs). This is different from many previous studies which used the growth factor domain of BMP9 and/or BMP10.

2020-03-04 | GSE134890 | GEO

Stimulation of HUVEC by BMP9/10

Project description:The experiment monitors the response of human umbilical vein endothelial cells to stimulation with BMP9 and BMP10

2021-02-05 | GSE160023 | GEO

BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver health

Project description:The liver is a largest solid organ in the body and is majorly composed of HCs, ECs, KCs, and HSCs, which spatially interact and cooperate each other to maintain liver homeostasis. However, the complexity and molecular mechanisms underlying the crosstalk between these different cell types remain to be revealed. Here, we generated mice with conditional deletion of Bmp9/10 in different liver cell types and demonstrated that HSCs was the major source of BMP9 and BMP10 in the liver. Using transgenic ALK1 (receptor for BMP9/10) reporter mice, we found that ALK1 is expressed on KCs and ECs other than HCs and HSCs. KCs from Bmp9/10HSC-KO (conditional deletion of Bmp9/10 from HSCs) mice lost their signature genes expression, such as ID1/3, CLEC4F, VSIG4 and CLEC2, and were replaced by monocyte-derived macrophages. ECs from Bmp9/10HSC-KO mice also lost their identity and were transdifferentiated to continuous ECs, ultimately leading to collagen IV deposition and liver fibrosis. Hepatic ECs expressed several angiocrine factors, such as BMP2, BMP6, Wnt2 and Rspo3, to regulate liver iron metabolism and metabolic zonation. We found that these angiocrine factors were significantly decreased in ECs from Bmp9/10HSC-KO mice, which further resulted in liver iron overload and disruption of HCs zonation. In addition, focal fatty liver spontaneously occurred in Bmp9/10HSC-KO mice at the age of 28W. In summary, we demonstrated that HSCs play a central role in mediating liver cell-cell crosstalk via production of BMP9/10 to maintain liver health.

2024-09-26 | GSE244429 | GEO

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