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Investigation of methylation level change of Endothelial cells and Magnesium-based alloy treated Endothelial cells

ABSTRACT: investigation of methylation level change of Endothelial cells and Magnesium-based alloy treated Endothelial cells

PROVIDER: PRJNA609113 | ENA |

REPOSITORIES: ENA

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investigation of methylation level change of Endothelial cells and Magnesium-based alloy treated Endothelial cells

Project description:We have completed the Arraystar Human m6A-mRNA&lncRNA Epitranscriptomic microarray analysis of the samples to validate the modulating role of Magnesium-based alloy on methylation of inflammatory genes.

2022-02-27 | GSE146038 | GEO

Next Generation Sequencing Facilitates Quantitative Analysis of Endothelial cells and Magnesium-based alloy treated Endothelial cells Transcriptomes

Project description:mRNA-seq was conducted to validate the changed mRNA expression of Endothelial cells after contacting with Magnesium-based alloy discs compared with normal Endothelial cells.

2022-03-01 | GSE146168 | GEO

ChIP sequencing for Endothelial cells and Magnesium-based alloy treated Endothelial cells

Project description:ChIP sequencing for Endothelial cells and Magnesium-based alloy treated Endothelial cells

| PRJNA609645 | ENA

Magnesium Hexacyanoferrate Nanocatalyst Attenuates Chemodrug-Induced Cardiotoxicity through Ferromodulation-Driven Anti-Apoptosis

Project description:For investigation of the pathology associated to Doxorubicin-induced cardiotoxicity and the therapeutic mechanism enabled by Dexrazoxane and synthetic Magnesium Hexacyanoferrate Nanocatalyst.

2022-09-26 | GSE213983 | GEO

Next Generation Sequencing Facilitates Quantitative Analysis of Endothelial cells and Magnesium-based alloy treated Endothelial cells Transcriptomes

Project description:Next Generation Sequencing Facilitates Quantitative Analysis of Endothelial cells and Magnesium-based alloy treated Endothelial cells Transcriptomes

| PRJNA609640 | ENA

Comparison of gene change in lymphoma cells after co-culture with endothelial cells

Project description:Mouse lymphoma cells were co-cultured with endothelial cells in serum/cytokine-free condition. To identify specific genetic changes, we compared lymphoma cells cultured in medium containing 10% fetal bovine serum with lymphoma cells co-cultured with endothelial cells. The experiment compared genetic change in lymphoma cells caused by co-culture with endothelial cells.

2013-12-31 | E-GEOD-46368 | biostudies-arrayexpress

Role of zyxin in the tension-induced expression change in endothelial cells

Project description:One of the hallmarks in hypertension is a pressure-induced change in endothelial cell phenotype. A cytoskeletal protein zyxin, which was seen to translocate from focal adhesion contacts to the nucleus in response to the increased wall tensionis, mediates the tension-induced endothelial signaling. Microarrays were used to detail the role of zyxin in the tension-induced expression changes in endothelial cells. Primary endothelial cells (Huvec) from four treatment groups were used for RNA extraction and hybridization on Affymetrix microarrays: wild type under normal condition, wild type under tension, Zyxin-SiRNA-treated under normal condition and Zyxin-SiRNA-treated under tension.

2010-08-16 | E-GEOD-17814 | biostudies-arrayexpress

Role of zyxin in the tension-induced expression change in endothelial cells

2010-08-16 | GSE17814 | GEO

Magnesium promotes vascularized osseointegration in diabetic states

Project description:The poor osseointegration of dental implants in diabetic patients has become a long-standing clinical problem. Magnesium has been proved to promote bone healing under normal conditions. Here, we elucidate the mechanism by which Mg2+ promotes vascularized osseointegration in diabetic status. We generated a diabetic mice model and demonstrated the alveolar bone healing was compromised, with significantly decreased angiogenesis. We then developed Mg-coating implants with hydrothermal synthesis. These implants sucessfully improved the vascularization and osseointegration in diabetic status. Mechanically, Mg2+ promoted the degradation of Kelch-like ECH associated protein 1 (Keap1) and the nucleation of nuclear factor erythroid 2-related factor 2 (Nrf2) by up-regulating the expression of sestrin 2 (SESN2) in endothelial cells, thus reducing the elevated levels of oxidative stress in mitochondria and relieving endothelial cell dysfunction under hyperglycemia. Altogether, our data proved that Mg2+ promoted vascularized osseointegration in diabetic mice by regulating endothelial mitochondrial metabolism.

2024-02-07 | GSE236139 | GEO

Transcription profiling of Bordetella pertussis GMT-1 magnesium sulfate shift

Project description:B. pertussis GMT-1 was grown in media containing magnesium sulfate to put the culture in the Bvg- phase. The cells were then washed and grown in media lacking magnesium sulfate and samples were harvested at time=0 and several time points beyond.

2006-03-31 | E-TABM-30 | biostudies-arrayexpress

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