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ChIP sequencing for Endothelial cells and Magnesium-based alloy treated Endothelial cells

ABSTRACT: ChIP sequencing for Endothelial cells and Magnesium-based alloy treated Endothelial cells

PROVIDER: PRJNA609645 | ENA |

REPOSITORIES: ENA

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Next Generation Sequencing Facilitates Quantitative Analysis of Endothelial cells and Magnesium-based alloy treated Endothelial cells Transcriptomes

Project description:mRNA-seq was conducted to validate the changed mRNA expression of Endothelial cells after contacting with Magnesium-based alloy discs compared with normal Endothelial cells.

2022-03-01 | GSE146168 | GEO

investigation of methylation level change of Endothelial cells and Magnesium-based alloy treated Endothelial cells

Project description:investigation of methylation level change of Endothelial cells and Magnesium-based alloy treated Endothelial cells

| PRJNA609113 | ENA

Next Generation Sequencing Facilitates Quantitative Analysis of Endothelial cells and Magnesium-based alloy treated Endothelial cells Transcriptomes

Project description:Next Generation Sequencing Facilitates Quantitative Analysis of Endothelial cells and Magnesium-based alloy treated Endothelial cells Transcriptomes

| PRJNA609640 | ENA

investigation of methylation level change of Endothelial cells and Magnesium-based alloy treated Endothelial cells

Project description:We have completed the Arraystar Human m6A-mRNA&lncRNA Epitranscriptomic microarray analysis of the samples to validate the modulating role of Magnesium-based alloy on methylation of inflammatory genes.

2022-02-27 | GSE146038 | GEO

ChIP sequencing for Endothelial cells and Magnesium-based alloy treated Endothelial cells

Project description:ChIP-seq analysis identifies that YAP directly binds to the promoter of inflammatory genes, inflammation-related transcription factors and co-transcription factors to induce their high expression in ECs.

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Magnesium promotes vascularized osseointegration in diabetic states

Project description:The poor osseointegration of dental implants in diabetic patients has become a long-standing clinical problem. Magnesium has been proved to promote bone healing under normal conditions. Here, we elucidate the mechanism by which Mg2+ promotes vascularized osseointegration in diabetic status. We generated a diabetic mice model and demonstrated the alveolar bone healing was compromised, with significantly decreased angiogenesis. We then developed Mg-coating implants with hydrothermal synthesis. These implants sucessfully improved the vascularization and osseointegration in diabetic status. Mechanically, Mg2+ promoted the degradation of Kelch-like ECH associated protein 1 (Keap1) and the nucleation of nuclear factor erythroid 2-related factor 2 (Nrf2) by up-regulating the expression of sestrin 2 (SESN2) in endothelial cells, thus reducing the elevated levels of oxidative stress in mitochondria and relieving endothelial cell dysfunction under hyperglycemia. Altogether, our data proved that Mg2+ promoted vascularized osseointegration in diabetic mice by regulating endothelial mitochondrial metabolism.

2024-02-07 | GSE236139 | GEO

GNPS - Human NVU - Endothelial cells

Project description:Human brain microvascular endothelial cells, adult cortical cells (hBMVECs, CellSystems, Kirkland, WA, USA used at passage 3 cultured and harvested as described in Proteomic and metabolomic characterization of human neurovascular unit cells in response to methamphetamine, Herland et al Adv Biosystems 2020

2020-07-20 | MSV000085788 | GNPS

Transcription profiling of Bordetella pertussis GMT-1 magnesium sulfate shift

Project description:B. pertussis GMT-1 was grown in media containing magnesium sulfate to put the culture in the Bvg- phase. The cells were then washed and grown in media lacking magnesium sulfate and samples were harvested at time=0 and several time points beyond.

2006-03-31 | E-TABM-30 | biostudies-arrayexpress

Morphine-treated Primary Brain Endothelial Cells LC-MS/MS DIA

Project description:This project aimed at investigating the impact of morphine exposure on brain endothelial cells via an in vitro monoculture of primary human brain microvascular endothelial cells (HBMECs) and state of the art mass spectrometry-based proteomics, using a data-independent acquisition (DIA) MS-based quantitative approach. HBMECS were exposed to morphine at three different concentrations (1, 10, 100 uM) and for two different time points (24h and 48h) to explore dose- and time-dependent effects.

2022-03-21 | PXD024351 | Pride

Endothelial-neuronal coupling revealed in a decoupled neurovascular unit based Organ-on-Chip approach.

Project description:This data set is for the article: Endothelial-neuronal coupling revealed in a decoupled neurovascular unit based Organ-on-Chip approach.

2017-08-24 | MSV000081480 | MassIVE

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