Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single cell RNAseq reconstruct normal and IPF lung epithelium

ABSTRACT: Single cell RNAseq reconstruct normal and IPF lung epithelium

PROVIDER: PRJNA612553 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Single cell RNAseq reconstruct normal and IPF lung epithelium

Project description:Tissue fibrosis is a common pathological outcome of chronic disease that markedly impairs organ function leading to morbidity and mortality. In the lung, idiopathic pulmonary fibrosis (IPF) is an insidious and fatal interstitial lung disease associated with declining pulmonary function. Single cell RNA sequencing was used to map epithelial cell types of the normal human airway and alveolaor as well as IPF explant tissue.

2020-09-24 | GSE146981 | GEO

Epigenome analysis of normal and IPF lung tissue samples

2012-06-30 | GSE35146 | GEO

Epigenome analysis of normal and IPF lung tissue samples

Project description:Genome wide DNA methylation profiling of normal and IPF lung samples. The Illumina human methylation 27 Beadchip was used to obtain DNA methylation profiles across approximately 27,000 CpGs samples. 2 normal samples, and 4 IPF samples Bisulphite converted DNA from the 12 samples were hybridised to the Illumina Infinium 27k Human Methylation Beadchip v1.2

2012-06-29 | E-GEOD-35146 | biostudies-arrayexpress

Expression data from lung tissues of IPF patients and Normal Control

Project description:Idiopathic pulmonary fibrosis (IPF) is a progressive lethal interstitial lung disease of unkown etiology with limited effective therapies. The pathogenic mechanisms of IPF remain unkown. Emerging evidences indicate that abnormal behaviors of fibroblasts in IPF are associated with a variety of genetic alterations and aberrant reactivation of developmental signaling pathways. We compared gene expression profiles in fibrotic lung tissues from IPF patients and normal lung tissues from patients with primary spontaneous pneumothorax using cDNA microarray to examine the mechnisms involved in the pathogenesis of IPF.

2015-08-15 | GSE72073 | GEO

Single cell reconstruction of human basal cell diversity in normal and IPF lung (single-cell RNAseq)

Project description:Declining lung function in patients with interstitial lung disease is accompanied by epithelial remodeling and progressive scarring of the gas-exchange region. There is a need to better understand the contribution of basal cell hyperplasia and associated mucosecretory dysfunction to the development of idiopathic pulmonary fibrosis (IPF). Single cell RNA sequencing was used to map epithelial cell types of the normal and IPF human airway. Organoid and ALI cultures were used to investigate functional properties of basal cell subtypes. We confirmed that Notch2 maintains undifferentiated basal cells and restrict basal-to-ciliated differentiation, and present evidence that Notch3 functions to restrain secretory differentiation. When characterizing single cell transcriptomes of the IPF lung we found a bias towards accumulation of the secretory primed basal cell subset.

2020-07-09 | GSE143706 | GEO

Human basal cell diversity in normal and IPF lung (bulk RNAseq)

Project description:Human basal cell diversity in normal and IPF lung (bulk RNAseq)

| PRJNA601419 | ENA

Human basal cell diversity in normal and IPF lung (bulk RNAseq)

Project description:Declining lung function in patients with interstitial lung disease is accompanied by epithelial remodeling and progressive scarring of the gas-exchange region. There is a need to better understand the contribution of basal cell hyperplasia and associated mucosecretory dysfunction to the development of idiopathic pulmonary fibrosis (IPF).We confirmed that Notch2 maintains undifferentiated basal cells and restrict basal-to-ciliated differentiation, and present evidence that Notch3 functions to restrain secretory differentiation. When characterizing single cell transcriptomes of the IPF lung we found a bias towards accumulation of the secretory primed basal cell subset.

2020-07-09 | GSE143705 | GEO

Human basal cell diversity in normal and IPF lung

Project description:Human basal cell diversity in normal and IPF lung

| PRJNA601416 | ENA

Transcriptomic analysis of normal and IPF lung fibroblast SSEA4+ and SSEA4- cells

Project description:Recently, SSEA4+ mesenchymal progenitor cells have been described in stromal cultures, where IPF (but not normal) progenitor cells show pathological properties both in vitro and in vivo. The purpose of this study is to determine differences between mesenchymal progenitor cells sorted from stromal cultures derived from the lung biopsies of IPF patients showing a slow progressive versus rapid progressive decline of lung function as previously defined (Trujillo, G et al Science trans med 2010). Further, both groups were also compared to their normal lung counterparts as well as SSEA4- mesenchymal progeny.

2018-02-13 | GSE103488 | GEO

Transcriptomic analysis of IPF lung-associated and normal peripheral blood T cells

Project description:Lung explant derived T cells were sorted from mechanically dissociated IPF lung explants and compared to CD4+ T cells magnetically sorted from the peripheral blood of normal donors.

2019-08-15 | GSE102751 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data