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Human basal cell diversity in normal and IPF lung (bulk RNAseq)

ABSTRACT: Human basal cell diversity in normal and IPF lung (bulk RNAseq)

PROVIDER: PRJNA601419 | ENA |

REPOSITORIES: ENA

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Human basal cell diversity in normal and IPF lung (bulk RNAseq)

Project description:Declining lung function in patients with interstitial lung disease is accompanied by epithelial remodeling and progressive scarring of the gas-exchange region. There is a need to better understand the contribution of basal cell hyperplasia and associated mucosecretory dysfunction to the development of idiopathic pulmonary fibrosis (IPF).We confirmed that Notch2 maintains undifferentiated basal cells and restrict basal-to-ciliated differentiation, and present evidence that Notch3 functions to restrain secretory differentiation. When characterizing single cell transcriptomes of the IPF lung we found a bias towards accumulation of the secretory primed basal cell subset.

2020-07-09 | GSE143705 | GEO

Single cell reconstruction of human basal cell diversity in normal and IPF lung (single-cell RNAseq)

Project description:Declining lung function in patients with interstitial lung disease is accompanied by epithelial remodeling and progressive scarring of the gas-exchange region. There is a need to better understand the contribution of basal cell hyperplasia and associated mucosecretory dysfunction to the development of idiopathic pulmonary fibrosis (IPF). Single cell RNA sequencing was used to map epithelial cell types of the normal and IPF human airway. Organoid and ALI cultures were used to investigate functional properties of basal cell subtypes. We confirmed that Notch2 maintains undifferentiated basal cells and restrict basal-to-ciliated differentiation, and present evidence that Notch3 functions to restrain secretory differentiation. When characterizing single cell transcriptomes of the IPF lung we found a bias towards accumulation of the secretory primed basal cell subset.

2020-07-09 | GSE143706 | GEO

Human basal cell diversity in normal and IPF lung

Project description:Human basal cell diversity in normal and IPF lung

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Single cell reconstruction of human basal cell diversity in normal and IPF lung (single-cell RNAseq)

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Single cell RNAseq reconstruct normal and IPF lung epithelium

Project description:Tissue fibrosis is a common pathological outcome of chronic disease that markedly impairs organ function leading to morbidity and mortality. In the lung, idiopathic pulmonary fibrosis (IPF) is an insidious and fatal interstitial lung disease associated with declining pulmonary function. Single cell RNA sequencing was used to map epithelial cell types of the normal human airway and alveolaor as well as IPF explant tissue.

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Bulk RNA-sequencing of ILC2s from IPF patients

Project description:To investigate the comprehensive mRNA expression profile of ILC2s from IPF patients, we performed bulk RNA-sequencing analysis of ILC2s sorted from IPF patients and healthy controls.

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Single cell RNAseq reconstruct normal and IPF lung epithelium

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Epigenome analysis of normal and IPF lung tissue samples

2012-06-30 | GSE35146 | GEO

Epigenome analysis of normal and IPF lung tissue samples

Project description:Genome wide DNA methylation profiling of normal and IPF lung samples. The Illumina human methylation 27 Beadchip was used to obtain DNA methylation profiles across approximately 27,000 CpGs samples. 2 normal samples, and 4 IPF samples Bisulphite converted DNA from the 12 samples were hybridised to the Illumina Infinium 27k Human Methylation Beadchip v1.2

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Expression data from lung tissues of IPF patients and Normal Control

Project description:Idiopathic pulmonary fibrosis (IPF) is a progressive lethal interstitial lung disease of unkown etiology with limited effective therapies. The pathogenic mechanisms of IPF remain unkown. Emerging evidences indicate that abnormal behaviors of fibroblasts in IPF are associated with a variety of genetic alterations and aberrant reactivation of developmental signaling pathways. We compared gene expression profiles in fibrotic lung tissues from IPF patients and normal lung tissues from patients with primary spontaneous pneumothorax using cDNA microarray to examine the mechnisms involved in the pathogenesis of IPF.

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