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Single-cell Transcriptome Analysis Dissects the Replicating Process of Pancreatic Beta Cells in Partial Pancreatectomy Model.

ABSTRACT: Single-cell Transcriptome Analysis Dissects the Replicating Process of Pancreatic Beta Cells in Partial Pancreatectomy Model.

PROVIDER: PRJNA640290 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12043376_1.fastq.gz	Fastqsanger.gz
	SRR12043376_2.fastq.gz	Fastqsanger.gz
	SRR12043377_1.fastq.gz	Fastqsanger.gz
	SRR12043377_2.fastq.gz	Fastqsanger.gz
	SRR12043378_1.fastq.gz	Fastqsanger.gz

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Single-cell Transcriptome Analysis Dissects the Replicating Process of Pancreatic Beta Cells in Partial Pancreatectomy Model.

Project description:We employed single-cell RNA sequencing of islets in young mice subjected to partial pancreatectomy (PPTx). Four clusters of pancreatic beta cells including a subpopulation of replicating beta cells. Pseudo-time course analysis clarified the gradual changes in gene expression from non-replicating beta cells to replicating ones. Upstream analysis visualized the transcriptional networks associated with beta cell replication by PPTx.

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