Ontology highlight
ABSTRACT:
PROVIDER: PRJNA720010 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:SAGE libraries made of squamous esophagus tissue, primary cell culture or esophageal squamous cell carcinoma Keywords: SAGE analysis of different tissues squamous esophagus biopsy was taken from 1 male metaplastic Barrett's esophagus patient. primary cell culture was from 1 male Barrett's esophagus patient. Esophageal squamous cell carcinoma was from a patient known to have ESCC
2006-06-28 | E-GEOD-5154 | biostudies-arrayexpress
Project description:Both genetic and epigenetic aberrations are linked by intricate crosstalk, and can either individually or in synergy lead to the development of cancer. Accumulating evidence suggests that epigenetic changes such as alterations in DNA methylation play a crucial role in ESCC. We performed a Illumina Infinium HumanMethylation450 BeadChip to examine the global methylation signature of esophageal squamous cell carcinoma of Chinese patients. DNA methylation profiles of esophageal squamous cell carcinoma (4 samples), paired adjacent normal surrounding tissues (4 samples) and normal esophagus mucosa from healthy individuals (4 samples) were generated using Infinium methylation 450K BeadChips from Illumina (Illumina, San Diego, USA).
2014-11-03 | E-GEOD-52826 | biostudies-arrayexpress
Project description:Although dysregulation of histamine and its receptor 4 (H4R) were widely and frequently appears in digestive carcinomas and was correlated with their malignancy and tumor proliferation, its existence and function in the esophagus and esophageal squamous cell carcinoma (ESCC) were still known. In our present study, we explored the expression and function of H4R in ESCC samples and cell lines. The results showed that H4R was overexpressed in poor differentiated ESCC samples and cell lines and correlated with median survival. H4R activation significantly not only blocked cell proliferation, cell cycle and invasion, but also induced the TE-2 xenograft inhibition and mice survival rate promotion. Mechanistic research demonstrated both metabolism (ACSS2) and non-metabolism (MAPK) related pathways were involved in H4R function, and H4R activation suppressed TGF-β1 via both above signaling. These findings firstly confirmed H4R overexpression in the esophagus cancer and its anti-tumor effects in the ESCC proliferation and invasion, which suggested that H4R was a potential target in therapy for ESCC.
2017-09-01 | GSE103373 | GEO
Project description:Esophageal squamous cell carcinoma (ESCC) is a heterogeneous cancer associated with high mortality rate. In India, it is the 6th most common cause of cancer-related mortality. In this study, we employed high-resolution mass spectrometry-based quantitative proteomics to characterize differential protein expression pattern associated with ESCC. We identified several differentially expressed proteins including PDPN, TOP2A, POSTN and MMP2 that were overexpressed in ESCC. In addition, we identified downregulation of esophagus tissue-enriched proteins such as SLURP1, PADI1, CSTA and small proline-rich proteins like SPRR3, SPRR2A, SPRR1A and CSTA, KRT4, KRT13 involved in squamous cell differentiation. We identified several overexpressed proteins belonging to 3q24-29 chromosomal region, corroborating CNV alterations in this region reported by several published studies. For example, we identified overexpression of SOX2, TP63, IGF2BP2 and RNF13 that are encoded by 3q26 region. Functional enrichment analysis revealed proteins involved in cell cycle pathways, DNA replication, spliceosome, and DNA repair pathways. We identified overexpression of multiple proteins that play a major role in alleviating ER stress. SYVN1/SEL1L complex forms the ER quality control machinery clearing misfolded proteins from ER. SYVN1 is an E3 ubiquitin ligase that ubiquitinates ER-resident proteins. There are also other non-canonical substrates of SYVN1 which are known to play a crucial role in tumor progression. Therefore, SYVN1 is a potential therapeutic target in ESCC.
2023-10-24 | PXD036238 | Pride
Project description:The purpose of this study is to explore the circRNAs expression profiles in the plasma from esophageal squamous cell carcinoma (ESCC) patients.The purpose of this study is to explore the circRNAs expression profiles in the plasma from esophageal squamous cell carcinoma (ESCC) patients.
2021-03-23 | GSE112496 | GEO
Project description:To understand the difference of protein expression between paired esophageal squamous cell carcinoma (ESCC) and adjacent normal tissues, we collected 10 paired ESCC and normal tissues from surgical resected specimems for high-throughput proteomic experiments. From comparative analysis, the dysregulated signaling pathways in ESCC could be uncovered.
2020-08-11 | PXD019834 | Pride
Project description:This study was designed to identify genes aberrantly expressed in esophageal squamous cell carcinoma (ESCC) cells. Three esophageal squamous cell carcinoma-derived cell lines and one normal human esophageal squamous cell line were analyzed.
2014-09-20 | E-GEOD-61587 | biostudies-arrayexpress
Project description:This study was designed to identify microRNAs aberrantly expressed in esophageal squamous cell carcinoma (ESCC) cells.
2014-09-20 | GSE61588 | GEO
Project description:DNA methylation in esophageal squamous cell carcinoma (ESCC)
2016-06-30 | GSE74693 | GEO
Project description:SAGE libraries made of squamous esophagus tissue, primary cell culture or esophageal squamous cell carcinoma Keywords: SAGE analysis of different tissues
2006-06-28 | GSE5154 | GEO