Project description:gnp3_tri33-arabidoseed. Embryo seed development. WP3: Biodiversity of seed traits: state-of-the-art. Analysis of the expression of small RNAs precursors in the seed development of Arabidopsis thaliana.
Project description:gnp3_tri33-arabidoseed. Embryo seed development. WP3: Biodiversity of seed traits: state-of-the-art. Analysis of the expression of small RNAs precursors in the seed development of Arabidopsis thaliana. 12 dye-swaps. Time course.
Project description:MicroRNA and other types of small regulatory RNAs play a crucial role in the regulation of gene expression in eukaryotes. Several distinct classes of small regulatory RNAs have been discovered in recent years. To extend the repertoire of small regulatory RNAs characterized in mammals and identify miRNA expressed upon viral infection we used Illumina’s ultrahigh throughput sequencing approach. Results presented in this study extend our knowledge of the biology and evolution of small regulatory RNAs in mammals and illuminate mechanisms of small RNA biogenesis and function. Keywords: Transcriptome analysis
Project description:A central goal of modern biology is to understand the molecular basis of phenotype evolution between species. Previously, the evolutionary profiling at the molecular level has been largely limited to the nucleotide level. Nevertheless, the genotype is translated to proteotype through comprehensive and gene-specific post-transcriptional regulations. Harnessing recently emerged consistent proteomic quantification methods, we here investigate the co-evolution processes across the transcriptomic, proteomic, and phosphoproteomic layers in skin fibroblasts from 11 common mammalian species. Altogether, we have generated a multi-species, multi-omics resource, the analysis of which significantly facilitates the understanding of gene expression, proteotype co-evolution, and biodiversity in mammals.
