Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Unravelling the sex-specific diversity and functions of adrenal gland macrophages (scRNA-Seq).

ABSTRACT: Unravelling the sex-specific diversity and functions of adrenal gland macrophages (scRNA-Seq).

PROVIDER: PRJNA838567 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Unravelling the sex-specific diversity and functions of adrenal gland macrophages (scRNA-Seq).

Project description:Despite the ubiquitous function of macrophages across the body, the diversity, origin, and function of adrenal gland macrophages remain largely unknown. We defined the heterogeneity of adrenal gland immune cells using single-cell RNA sequencing and used genetic models to explore the developmental mechanisms yielding to macrophage diversity. We defined populations of monocyte-derived and embryonically seeded adrenal gland macrophages and identified a female-specific subset with low MHC-II expression. In adulthood, monocyte recruitment dominated adrenal gland macrophage maintenance in female mice, while self-proliferation was more important in males. Adrenal gland macrophage sub-tissular distribution followed a sex-dimorphic pattern, with MHC-IIlow macrophages located at the border between the cortex and the medulla. Macrophage sex dimorphism depended on the presence of the cortical Xzone. Forcing X-zone maintenance in males, or its degradation in females, directly impacted the presence of MHC-IIlow macrophages. Adrenal gland macrophage depletion resulted in altered tissue homeostasis, modulated lipid- metabolism and decreased local aldosterone production during stress exposure. Overall, these data explain the heterogeneity of adrenal gland macrophages and point toward sexrestricted distribution and functions of these cells.

2022-05-23 | GSE203095 | GEO

Unravelling the sex-specific diversity and functions of adrenal gland macrophages (RNA-Seq).

2022-05-23 | GSE203096 | GEO

Unravelling the sex-specific diversity and functions of adrenal gland macrophages

Project description:Unravelling the sex-specific diversity and functions of adrenal gland macrophages

| PRJNA838565 | ENA

Unravelling the sex-specific diversity and functions of adrenal gland macrophages (RNA-Seq).

Project description:Unravelling the sex-specific diversity and functions of adrenal gland macrophages (RNA-Seq).

| PRJNA838566 | ENA

Unravelling the sex-specific diversity and functions of adrenal gland macrophages.

Project description:Despite the ubiquitous function of macrophages across the body, the diversity, origin, and function of adrenal gland macrophages remain largely unknown. We define the heterogeneity of adrenal gland immune cells using single-cell RNA sequencing and use genetic models to explore the developmental mechanisms yielding macrophage diversity. We define populations of monocyte-derived and embryonically seeded adrenal gland macrophages and identify a female-specific subset with low major histocompatibility complex (MHC) class II expression. In adulthood, monocyte recruitment dominates adrenal gland macrophage maintenance in female mice. Adrenal gland macrophage sub-tissular distribution follows a sex-dimorphic pattern, with MHC class IIlow macrophages located at the cortico-medullary junction. Macrophage sex dimorphism depends on the presence of the cortical X-zone. Adrenal gland macrophage depletion results in altered tissue homeostasis, modulated lipid metabolism, and decreased local aldosterone production during stress exposure. Overall, these data reveal the heterogeneity of adrenal gland macrophages and point toward sex-restricted distribution and functions of these cells.

| S-EPMC9210345 | biostudies-literature

Adrenal gland macrophages regulate glucocorticoid production through Trem2 and TGFβ [scRNA-seq]

Project description:To elucidate how adrenal gland immune cells response to acute or chronic stressors

2024-06-03 | GSE268521 | GEO

Unravelling the sex-specific diversity and functions of adrenal gland macrophages

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-05-23 | GSE203097 | GEO

WGBS from adrenal gland (ENCSR741FVM)

Project description:WGBS sequencing from adrenal gland tissue For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

2019-03-03 | GSE127311 | GEO

WGBS from adrenal gland (ENCSR042LOG)

2019-03-03 | GSE127282 | GEO

eCLIP from adrenal gland (ENCSR096YAP)

Project description:eCLIP control experiment on adrenal gland against HNRNPU For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODE_Data_Use_Policy_for_External_Users_03-07-14.pdf

2017-01-03 | GSE91477 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data