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AMPK gamma3 knock-out and mutant (R225Q) transgenic mice compared to corresponding wild type littermates

ABSTRACT: AMPK gamma3 knock-out and mutant (R225Q) transgenic mice compared to corresponding wild type littermates

OTHER RELATED OMICS DATASETS IN: E-GEOD-4065E-GEOD-4063

PROVIDER: PRJNA95187 | ENA |

REPOSITORIES: ENA

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AMPK gamma3 knock-out and mutant (R225Q) transgenic mice compared to corresponding wild type littermates

Project description:This SuperSeries is composed of the following subset Series: GSE4063: Gene expression in skeletal muscle in AMPK gamma3 knock-out mice and wild type littermates GSE4065: Gene expression in skeletal muscle in AMPK gamma3 mutant (R225Q) transgenic mice and wild type littermates. Note: GSE4063 and GSE4065 are not directly comparable. Keywords: SuperSeries Refer to individual Series

2006-02-15 | E-GEOD-4067 | biostudies-arrayexpress

Gene expression in skeletal muscle in AMPK gamma3 knock-out mice and wild type littermates

Project description:Analysis of AMPK gamma3-dependent transcriptional responses by analyzing global gene expression in the white portion of the gastrocnemius muscle in AMPK gamma3 knock-out mice and corresponding wild type littermates. Keywords: Genetic modification

2006-02-15 | GSE4063 | GEO

Gene expression in skeletal muscle in AMPK gamma3 mutant (R225Q) transgenic mice and wild type littermates.

Project description:Analysis of AMPK gamma3-dependent transcriptional responses by analyzing global gene expression in the white portion of the gastrocnemius muscle in AMPK gamma3 mutant (R225Q) transgenic mice and corresponding wild type littermates. Keywords: Genetic modification

2006-02-15 | GSE4065 | GEO

Transcription profiling of skeletal muscle in AMPK gamma3 mutant (R225Q) transgenic mice and wild type littermates

Project description:Analysis of AMPK gamma3-dependent transcriptional responses by analyzing global gene expression in the white portion of the gastrocnemius muscle in AMPK gamma3 mutant (R225Q) transgenic mice and corresponding wild type littermates.

2007-06-26 | E-GEOD-4065 | biostudies-arrayexpress

Transcription profiling of mouse skeletal muscle of AMP-activated protein kinase gamma3 R225Q transgenic versus knock-out

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AMPK gamma3 knock-out and mutant (R225Q) transgenic mice compared to corresponding wild type littermates

Project description:Note: GSE4063 and GSE4065 are not directly comparable. This SuperSeries is composed of the SubSeries listed below.

2006-02-15 | GSE4067 | GEO

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Project description:Gene expression in skeletal muscle in AMPK gamma3 knock-out mice and wild type littermates

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Project description:Gene expression in skeletal muscle in AMPK gamma3 mutant (R225Q) transgenic mice and wild type littermates.

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Phosphorylation of TET2 by AMPK is indispensable in myogenic differentiation [RNA-seq]

Project description:TET-mediated oxidation of 5-mC participates in both passive and active DNA demethylation, which exerts a significant influence on diverse biological processes. Mass spectrometry has identified multiple phosphorylation sites of TET2. However, the functions of these phosphosites and their corresponding kinases are mostly unknown. Here we showed that AMP-activated protein kinase (AMPK) phosphorylates murine TET2 at the serine residue 97 (S97), enhances TET2 stability through promoting its binding to 14-3-3β. AMPK ablation resulted in decreased global 5-hmC levels at the myotube stages, severe differentiation defects of C2C12 cells and, significantly, total loss of expression of Pax7. Genome-wide analyses revealed increased DNA methylation at genic and enhancer regions of AMPK-null myoblasts and myotubes. Using CRISPR/Cas9 technology, we showed that a novel enhancer, which is hypermethylated in AMPK-null cells, regulates Pax7 expression. The phospho-mimicking mutant, TET2-S97E, could partly rescue the differentiation defect in AMPK ablated C2C12 cells. Together, our data demonstrated that AMPK is a critical regulator of myogenesis, partly through phosphorylating TET2.

2019-06-06 | GSE126370 | GEO