Dataset Information
O-mut-DR
Ontology highlight
ABSTRACT:
REANALYSIS of: PXD002161
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Caenorhabditis Elegans (c. Elegans)
SUBMITTER:
PROVIDER: PAe005567 | PeptideAtlas | 2013-12-31
REPOSITORIES: PeptideAtlas
Publications
Reduced insulin/insulin-like growth factor-1 signaling and dietary restriction inhibit translation but preserve muscle mass in Caenorhabditis elegans.
Molecular & cellular proteomics : MCP 20130903 12
Reduced signaling through the C. elegans insulin/insulin-like growth factor-1-like tyrosine kinase receptor daf-2 and dietary restriction via bacterial dilution are two well-characterized lifespan-extending interventions that operate in parallel or through (partially) independent mechanisms. Using accurate mass and time tag LC-MS/MS quantitative proteomics, we detected that the abundance of a large number of ribosomal subunits is decreased in response to dietary restriction, as well as in the da ...[more]
