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Y-mut-DR

ABSTRACT: Young, daf2 mutants, dietary restriction group

REANALYSIS of: PXD002161

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Caenorhabditis Elegans (c. Elegans)

SUBMITTER:

PROVIDER: PAe005590 | PeptideAtlas | 2013-12-31

REPOSITORIES: PeptideAtlas

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Reduced insulin/insulin-like growth factor-1 signaling and dietary restriction inhibit translation but preserve muscle mass in Caenorhabditis elegans.

Depuydt Geert G Xie Fang F Petyuk Vladislav A VA Shanmugam Nilesh N Smolders Arne A Dhondt Ineke I Brewer Heather M HM Camp David G DG Smith Richard D RD Braeckman Bart P BP

Molecular & cellular proteomics : MCP 20130903 12

Reduced signaling through the C. elegans insulin/insulin-like growth factor-1-like tyrosine kinase receptor daf-2 and dietary restriction via bacterial dilution are two well-characterized lifespan-extending interventions that operate in parallel or through (partially) independent mechanisms. Using accurate mass and time tag LC-MS/MS quantitative proteomics, we detected that the abundance of a large number of ribosomal subunits is decreased in response to dietary restriction, as well as in the da ...[more]

PMID: 24002365

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