Proteomics

Dataset Information

0

GPVI-stimulated platelet subproteomes


ABSTRACT: CRP cytosol donor 1

INSTRUMENT(S): instrument model

ORGANISM(S): Homo Sapiens (human)

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Bernice Wright  

PROVIDER: PRD000535 | Pride | 2011-12-05

REPOSITORIES: Pride

Dataset's files

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Publications

Analysis of protein networks in resting and collagen receptor (GPVI)-stimulated platelet sub-proteomes.

Wright Bernice B   Stanley Ronald G RG   Kaiser William J WJ   Mills Davinia J DJ   Gibbins Jonathan M JM  

Proteomics 20111104 23


Proteomics approaches have made important contributions to the characterisation of platelet regulatory mechanisms. A common problem encountered with this method, however, is the masking of low-abundance (e.g. signalling) proteins in complex mixtures by highly abundant proteins. In this study, subcellular fractionation of washed human platelets either inactivated or stimulated with the glycoprotein (GP) VI collagen receptor agonist, collagen-related peptide, reduced the complexity of the platelet  ...[more]

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