Comparison of cell-derived extracellular matrix isolated from LX-2 and HFF cells and analysed by LC-MS/MS
Ontology highlight
ABSTRACT:
INSTRUMENT(S): 4000 Q TRAP, instrument model
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Hepatic Stellate Cell, Fibroblast
SUBMITTER: 
Jon Humphries
PROVIDER: PRD000680 | Pride | 2012-06-25
REPOSITORIES: Pride
Dataset's files
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Publications
Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver.
Rashid S Tamir ST Humphries Jonathan D JD Byron Adam A Dhar Ameet A Askari Janet A JA Selley Julian N JN Knight David D Goldin Robert D RD Thursz Mark M Humphries Martin J MJ
Journal of proteome research 20120628 8
Activation of hepatic stellate cells (HSCs) and subsequent uncontrolled accumulation of altered extracellular matrix (ECM) underpin liver fibrosis, a wound healing response to chronic injury, which can lead to organ failure and death. We sought to catalogue the components of fibrotic liver ECM to obtain insights into disease etiology and aid identification of new biomarkers. Cell-derived ECM was isolated from the HSC line LX-2, an in vitro model of liver fibrosis, and compared to ECM from human ...[more]
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