Proteomics

Dataset Information

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Comparative study of secretomes and vesicular subproteomes from Pseudomonas aeruginosa (PAO1)


ABSTRACT: Comparative study of secretomes and vesicular subproteomes from Pseudomonas aeruginosa (PAO1)

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Pseudomonas Aeruginosa

SUBMITTER: Sergio Ciordia  

LAB HEAD: Juan Pablo Albar Ramirez

PROVIDER: PXD000687 | Pride | 2018-10-27

REPOSITORIES: Pride

Dataset's files

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MIAPE_MSI_8236_report.html Other
MIAPE_MSI_8237_report.html Other
MIAPE_MSI_8238_report.html Other
MIAPE_MSI_8239_report.html Other
MIAPE_MSI_8240_report.html Other
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Publications

Quantitative proteomics unravels that the post-transcriptional regulator Crc modulates the generation of vesicles and secreted virulence determinants of Pseudomonas aeruginosa.

Reales-Calderón Jose Antonio JA   Corona Fernando F   Monteoliva Lucía L   Gil Concha C   Martínez Jose Luis JL  

Journal of proteomics 20150621 Pt B


Recent research indicates that the post-transcriptional regulator Crc modulates susceptibility to antibiotics and virulence in Pseudomonas aeruginosa. Several P. aeruginosa virulence factors are secreted or engulfed in vesicles. To decipher the Crc modulation of P. aeruginosa virulence, we constructed a crc deficient mutant and measure the proteome associated extracellular vesicles and the vesicle-free secretome using iTRAQ. Fifty vesicle-associated proteins were more abundant and 14 less abunda  ...[more]

Publication: 1/2

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