Proteomics

Dataset Information

0

Proteomic Analysis of Mouse Liver Microsomes by 2D-LC-MSMS


ABSTRACT: Liver plays a crucial role in numerous metabolic processes and therefore is the primary target of study in drug discovery and molecular toxicology. Devising an appropriate analytical strategy for an efficient analysis of the liver samples has been a major concern in proteomics. The aim of this study was to develop an LC-MS based analytical method for identification of liver proteins with adequate peptide-level confidence and protein sequence coverage. The present dataset will improve the existing knowledge on the proteins identified in mouse liver microsomes.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Hepatocyte, Liver

DISEASE(S): Disease Free

SUBMITTER: Lekha Sleno  

LAB HEAD: Lekha Sleno

PROVIDER: PXD000731 | Pride | 2015-03-26

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
MLM.group.gz Other
MLM.mgf Mgf
MLM.xml Xml
MLM__FDR.xlsx Xlsx
MMP_1_1.wiff Wiff
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Publications

Dataset from proteomic analysis of rat, mouse, and human liver microsomes and S9 fractions.

Golizeh Makan M   Schneider Christina C   Ohlund Leanne B LB   Sleno Lekha L  

Data in brief 20150224


Rat, mouse and human liver microsomes and S9 fractions were analyzed using an optimized method combining ion exchange fractionation of digested peptides, and ultra-high performance liquid chromatography (UHPLC) coupled to high resolution tandem mass spectrometry (HR-MS/MS). The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium (http://proteomecentral.proteomexchange.org) via the PRIDE partner repository (Vizcaíno et al., 2013 [1]) with the dataset identifier  ...[more]

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