Dataset Information

Human oral cancer brush biopsy iTRAQ

ABSTRACT: iTRAQ-based comparison of proteins derived from oral cells collected by brush biopsy. Protein abundance levels compared between oral pre-malignant cells, oral cancer cells and healthy normal cells, all collected from human patients. Two separate iTRAQ labeled biological replicate analyses were conducted.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Oral Mucosa, Epithelial Cell

DISEASE(S): Oral Cavity Cancer

SUBMITTER: Tim Griffin

LAB HEAD: Timothy Jon Griffin

PROVIDER: PXD000807 | Pride | 2014-05-07

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	Mudpit_tgriffin_yang3386_082312_11941_iTQ_brushbiop_13_25 (Sequest).mzid_Mudpit_tgriffin_yang3386_082312_11941_iTQ_brushbiop_13_25_(Sequest).pride.mgf.gz	Mzid
	Mudpit_tgriffin_yang3386_082312_11941_iTQ_brushbiop_13_25 (Sequest).pride.mztab.gz	Mztab
	Mudpit_tgriffin_yang3386_082312_11941_iTQ_brushbiop_13_25Sequest.mzid.gz	Mzid
	Mudpit_tgriffin_yang3386_082312_11941_iTQ_brushbiop_13_25Sequest.mzid_Mudpit_tgriffin_yang3386_082312_11941_iTQ_brushbiop_13_25_Sequest.MGF	Mzid
	Mudpit_tgriffin_yang3386_101212_12226_iTQ4_12_28 (Sequest).mzid_Mudpit_tgriffin_yang3386_101212_12226_iTQ4_12_28_(Sequest).pride.mgf.gz	Mzid

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Publications

Quantitative proteomic analysis of oral brush biopsies identifies secretory leukocyte protease inhibitor as a promising, mechanism-based oral cancer biomarker.

Yang Ya Y Rhodus Nelson L NL Ondrey Frank G FG Wuertz Beverly R K BR Chen Xiaobing X Zhu Yaqin Y Griffin Timothy J TJ

PloS one 20140418 4

A decrease in the almost fifty percent mortality rate from oral cancer is needed urgently. Improvements in early diagnosis and more effective preventive treatments could affect such a decrease. Towards this end, we undertook for the first time an in-depth mass spectrometry-based quantitative shotgun proteomics study of non-invasively collected oral brush biopsies. Proteins isolated from brush biopsies from healthy normal tissue, oral premalignant lesion tissue (OPMLs), oral squamous cell carcino ...[more]

PMID: 24748380

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