Proteomics

Dataset Information

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Senescence 1 - Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation


ABSTRACT: Bag3 and MVP regulate apoptosis resistance in Therapy Induced Senescence (TIS)

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

DISEASE(S): Breast Cancer

SUBMITTER: judith coppinger  

LAB HEAD: Judith Coppinger

PROVIDER: PXD001012 | Pride | 2015-08-21

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
517sen1thy-01.RAW Raw
517sen1thy-01.mgf Mgf
517sen1thy-01.pride.mgf.gz Mgf
517sen1thy-02.RAW Raw
517sen1thy-02.mgf Mgf
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Publications

Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation.

Pasillas Martina P MP   Shields Sarah S   Reilly Rebecca R   Strnadel Jan J   Behl Christian C   Park Robin R   Yates John R JR   Klemke Richard R   Gonias Steven L SL   Coppinger Judith A JA  

Molecular & cellular proteomics : MCP 20140705 1


Senescence is a prominent solid tumor response to therapy in which cells avoid apoptosis and instead enter into prolonged cell cycle arrest. We applied a quantitative proteomics screen to identify signals that lead to therapy-induced senescence and discovered that Bcl2-associated athanogene 3 (Bag3) is up-regulated after adriamycin treatment in MCF7 cells. Bag3 is a member of the BAG family of co-chaperones that interacts with Hsp70. Bag3 also regulates major cell-signaling pathways. Mass spectr  ...[more]

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